Detailed information of TA system TA141564

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4212452..4214023
• Replicon: chromosome
• Accession: NZ_CP045257
• Organism: Proteus mirabilis strain L90-1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GCE56_RS20255
• Protein ID: WP_063073818.1
• Coordinates: 4212452..4213765 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GCE56_RS20260
• Protein ID: WP_049203075.1
• Coordinates: 4213766..4214023 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE56_RS20235	4207621..4208424	+	804	WP_063073815.1	energy transducer TonB	-
GCE56_RS20240	4208478..4210439	-	1962	WP_063073816.1	hypothetical protein	-
GCE56_RS20245	4210471..4211400	-	930	WP_004246518.1	metallophosphoesterase	-
GCE56_RS20250	4211585..4212049	-	465	WP_063073817.1	DUF1097 domain-containing protein	-
GCE56_RS20255	4212452..4213765	-	1314	WP_063073818.1	type II toxin-antitoxin system HipA family toxin	Toxin
GCE56_RS20260	4213766..4214023	-	258	WP_049203075.1	helix-turn-helix domain-containing protein	Antitoxin
GCE56_RS20265	4214172..4215536	-	1365	WP_004246513.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
GCE56_RS20270	4215674..4217314	-	1641	WP_004246512.1	membrane protein insertase YidC	-
GCE56_RS20275	4217317..4217577	-	261	WP_012368639.1	membrane protein insertion efficiency factor YidD	-
GCE56_RS20280	4217541..4217900	-	360	WP_004246510.1	ribonuclease P protein component	-
GCE56_RS20285	4217918..4218061	-	144	WP_004246509.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49674.86 Da
• Isoelectric Point: 6.7643

>T141564 WP_063073818.1 NZ_CP045257:c4213765-4212452 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLVAIGADTVGALRLLPSGSTPANIKKIEYQKLNDIELEKILLGYKSNTPLGMLKKYTDFRISIAGAQEKTA
LLLKDNDWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T141564 NZ_CP060015:2245715-2246128 [Mycobacterium malmoense]
GTGGCGGTGACACGCTGGCTGATCGACAAGTCCGCGTACGCACGTCTTCAGCTCGGCCAGGCATCCAACGTCGACCAGTG
GAACGCCCGCATTGGACGTGGCTTGGTTCACCTGTCCACGATCACCCGGCTCGAGCTCGGGTACTCGGCCCGCAACGGTC
ATGCTGGGCGACGCCAGTTCGCCTCGCCGCCCTTGTCCCTGATGCCGGTGGAATACTTGACGCCTGCCATCGAGGACCGA
GCGCTAGAGGTTCAGATGCTTCTGGCCGACCGGGGCCAGCACCGCGCGCCGTCGATCCCCGACTTGCTCGTCGCCGCCAC
CGCCGAGAAGGCCGGGCTGCGGGTTCTGGTGGCGGACAAAGACTTCGACTTGATCGCCAATATCACCGGCCAGCCAATCG
ACGCCTTAACGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT141564 WP_049203075.1 NZ_CP045257:c4214023-4213766 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFEINPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT141564 NZ_CP060015:2245500-2245724 [Mycobacterium malmoense]
ATGCCGGACGTCTTGATCCGAGGCCTGTCCGAGGAGGCCGTCGAAAATATCGATGCCGCCGCGGCAGCTCTCGGACTGTC
ACGTAATGAATACTTGCGGCGCACGTTTGAGCGAGCGGCCGTCCAGCCGGTCAAAAAGACAGTCACCGCCGAAGACTGGC
AACGGTCCGCCGAGACGTTCGCCGATCTCGCCGATCCTGATGTCATGGCGGCCGCGTGGCGGTGA