Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3992772..3993573 Replicon chromosome
Accession NZ_CP045257
Organism Proteus mirabilis strain L90-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag GCE56_RS19215 Protein ID WP_001094437.1
Coordinates 3992772..3993149 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag GCE56_RS19220 Protein ID WP_001390338.1
Coordinates 3993196..3993573 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE56_RS19185 3988195..3988515 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
GCE56_RS19190 3989304..3989438 + 135 Protein_3659 transposase -
GCE56_RS19195 3989563..3990597 - 1035 WP_017628609.1 virulence RhuM family protein -
GCE56_RS19200 3991140..3991985 - 846 WP_001274561.1 DUF4942 domain-containing protein -
GCE56_RS19205 3992070..3992357 - 288 WP_060589331.1 DUF957 domain-containing protein -
GCE56_RS19210 3992287..3992775 - 489 WP_000761716.1 hypothetical protein -
GCE56_RS19215 3992772..3993149 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
GCE56_RS19220 3993196..3993573 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GCE56_RS19225 3993736..3993957 - 222 WP_000692345.1 DUF987 domain-containing protein -
GCE56_RS19230 3994020..3994496 - 477 WP_001535682.1 RadC family protein -
GCE56_RS19235 3994512..3994985 - 474 WP_000855064.1 antirestriction protein -
GCE56_RS19240 3995080..3995327 - 248 Protein_3669 antirestriction protein -
GCE56_RS19245 3995327..3996145 - 819 WP_001535681.1 DUF945 domain-containing protein -
GCE56_RS19250 3996300..3996458 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T141563 WP_001094437.1 NZ_CP045257:c3993149-3992772 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T141563 NZ_CP060015:c2152695-2151865 [Mycobacterium malmoense]
GTGGACTTGGAGTCTCGACCACCGTGGTCGAACAACGCGCTGCGTCGTCTTGGGGCGGCGCTTCGCGATGGAGTCGACCC
GCCGATCGATTGCCCGTCGTACGCAGACGTGATGTTGTGGCACTTCGACCTGGCTGCCGAAGTGCAGGATCAAATCGAGA
GCGGGAGTTGGTCGATCAGGTCGGAGTTGTTGGCGACCAAAGCAGGACGGCTGACGCCGGATTTACAGGTTAGCTCACGC
CCAAAGACCCAAGACACGTTGGTGGAAAAGCTGCAACGGCAGCCCAGCCTGCAACTGAATGCTGTCCAAGACCTCGCTGG
TGTTCGCATTGACGCCGACCTGCTGTTGGGCGAACAGATGAGCCTCGCTCGGGAGATCGCCAGTTACTTCTGTGCGGACG
AGTCAGCCATCCATGATCTGCGCGATGGCACGCACGCTGGTTACCGTGGCGTTCATGTCTGGCTTCGGTTGCCTGCTGGG
CGGGTCGAAATACAGATTCGGACGATTCTTCAAAGCCTGTGGGCGAACCTGTTTGAGAAGCTCGCAGATGAAGTCGGCCG
GGGCATCCGCTACGGCGAACCTGTCGAACCGTCGCCCGGCGTAGACGTAGGACGGATTCAGCGCGCGGTGCAGAGCATGC
AGGAATTCTCGGCAAAGGTGGCAGCTAGCGAAGCGGACTGGCAACAGTGTTCCGAGATCGAAGACCCTGGTCGGCGCGGA
GTCGCGCTCGGAACAGCCGCCATGGACAGGGCGATGTGGGTCGGTTTGGTGGCTTATGCTGCACAGAAGGCTAGTGGTGA
GGCTGAGTCCTCCAAAGGGGAAGATGGGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT141563 WP_001390338.1 NZ_CP045257:c3993573-3993196 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT141563 NZ_CP060015:c2151863-2151633 [Mycobacterium malmoense]
ATGGCTGGTTATGTCGTCGAATACAACCGGCGCACCCACGAGCGTCGCATCACCGAGTTCGTGACCACGCGCGAGGCGAT
GGAGTACCGGCTGAAGCTCGAAGCCGAGCGCACCGACAAGAACGTGGAGATCGCCGCGCTCGTTAGCAAGTCGCTAGACA
CCTTGAAGCAAACCCACTCGCGTTACTTCAGCGGCGCAGAACTGGCTGCAGAAGACTGCATGCTGACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References