Detailed information of TA system TA141562

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3829388..3830087
• Replicon: chromosome
• Accession: NZ_CP045257
• Organism: Proteus mirabilis strain L90-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GCE56_RS18465
• Protein ID: WP_017628658.1
• Coordinates: 3829388..3829774 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: GCE56_RS18470
• Protein ID: WP_004246828.1
• Coordinates: 3829767..3830087 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE56_RS18450	3825407..3825988	-	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-
GCE56_RS18455	3826239..3827144	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
GCE56_RS18460	3827154..3829226	+	2073	WP_017628659.1	glycine--tRNA ligase subunit beta	-
GCE56_RS18465	3829388..3829774	+	387	WP_017628658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GCE56_RS18470	3829767..3830087	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
GCE56_RS18475	3830136..3830570	-	435	WP_004246827.1	hypothetical protein	-
GCE56_RS18480	3830563..3831447	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
GCE56_RS18485	3831662..3832948	-	1287	WP_063073863.1	DUF3748 domain-containing protein	-
GCE56_RS18490	3833085..3833702	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
GCE56_RS18495	3834003..3834626	+	624	WP_004246821.1	guanylate kinase	-
GCE56_RS18500	3834681..3834956	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14322.65 Da
• Isoelectric Point: 10.0826

>T141562 WP_017628658.1 NZ_CP045257:3829388-3829774 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVRYD

Nucleotide

• Length: 387 bp

>T141562 NZ_CP060015:c2067327-2066935 [Mycobacterium malmoense]
GTGAAGCGCTACCTCGTCGACACCCATGTGTGGCTGTGGATGCAGTCCGACCCCGACCGGCTACGCGACGAAGCACGCGA
AATCGTCCAGGACGCCCGCAACAGCGTTCTCCTCTCGGCCGCCAGCGCCTGGGAGATCGCGATCAAATACCGGCTCGGCA
AACTCCCGTTGCCCGAAGCGCCGGCCTCCTACCTGCCCGATCGGATGCGCCGTTCCGGAACGTCTCCGCTGCCGGTCGAC
CACGCACACGCGCTGCGAACCGCCGAGCTTCCGGATCACCACCGGGATCCGTTCGACCGGCTCCTCATCGCCCAGGCGCA
GCTGCTCGACCTGACGATCATGACGGCCGACGAACAGCTGTCTGCCTATGACGTCGCGGTCGTCGCGGCATGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT141562 WP_004246828.1 NZ_CP045257:3829767-3830087 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT141562 NZ_CP060015:c2067569-2067324 [Mycobacterium malmoense]
ATGACTAAGTCCGCTGCCATCAGGGTCGGCGTCCACGAGGCGAAGACCCGCATGTCGGAGCTGCTGCGGCTGGTCGACAG
CGGGCAGGAGATCGAGATCGCCCGCGGCGGTGAACCCGTGGCCAAGCTGGTGCCGTTTCGCTCCCCAGAGATCCGCCGCT
TGGGCATAGACCACGGCGTCTACGCCGTGCCCGACGATTTCGATGCACCGTTACCCGACGACGTCCTCCACAGCTTCTAC
CGGTGA

Structures

Antitoxin

• AlphaFold DB: B4EZ97