Detailed information of TA system TA141561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): VapXD/-
• Location: 3394691..3395161
• Replicon: chromosome
• Accession: NZ_CP045257
• Organism: Proteus mirabilis strain L90-1

Toxin (Protein)

• Gene name: VapD
• Uniprot ID: A0A8E4FU70
• Locus tag: GCE56_RS16485
• Protein ID: WP_060555119.1
• Coordinates: 3394883..3395161 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: VapX
• Uniprot ID: A0A8E4FTC4
• Locus tag: GCE56_RS16480
• Protein ID: WP_060555126.1
• Coordinates: 3394691..3394879 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE56_RS16445	3389999..3391198	-	1200	WP_049218680.1	lipoprotein-releasing ABC transporter permease subunit LolC	-
GCE56_RS16450	3391500..3391901	+	402	WP_049218678.1	PPC domain-containing protein	-
GCE56_RS16455	3392318..3392719	-	402	WP_060555124.1	phage holin family protein	-
GCE56_RS16460	3392801..3393154	-	354	WP_060555123.1	hypothetical protein	-
GCE56_RS16465	3393226..3393474	-	249	WP_060555122.1	DUF883 family protein	-
GCE56_RS16470	3393924..3394271	+	348	WP_060555121.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GCE56_RS16475	3394271..3394570	+	300	WP_060555120.1	XRE family transcriptional regulator	-
GCE56_RS16480	3394691..3394879	+	189	WP_060555126.1	DUF5397 family protein	Antitoxin
GCE56_RS16485	3394883..3395161	+	279	WP_060555119.1	virulence factor	Toxin
GCE56_RS16490	3395634..3397124	+	1491	WP_060555118.1	YadA-like family protein	-
GCE56_RS16495	3397311..3397385	-	75	Protein_3127	IS200/IS605 family transposase	-
GCE56_RS16500	3397379..3397486	-	108	Protein_3128	transposase	-
GCE56_RS16505	3397536..3397742	-	207	WP_060555117.1	hypothetical protein	-
GCE56_RS16510	3397739..3398323	-	585	WP_114141483.1	AAA family ATPase	-
GCE56_RS16515	3398830..3399348	-	519	WP_060555115.1	ClbS/DfsB family four-helix bundle protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(J)	-	3264743..3440274	175531

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Virulence-associated protein D / CRISPR associated protein Cas2 (1-86)

Antitoxin

• Protein of unknown function DUF5397 (5-62)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10589.85 Da
• Isoelectric Point: 6.4606

>T141561 WP_060555119.1 NZ_CP045257:3394883-3395161 [Proteus mirabilis]
MYAISFDLTVADTEKHHPKGVSQAYNDISSTLKRYGFERIQGSLYTNSDENMANLFQAMNALKALEWFPNSVRDIRAFRI
EQWSDFTSSMKG

Nucleotide

• Length: 279 bp

>T141561 NZ_CP060015:2066586-2066888 [Mycobacterium malmoense]
GTGATCAGCCCGGGCGACATCGTCCCGCGTCGCGGCAGCGACCACGAGCTGTACGTTGTCGTCCTGTCCAACGCGATCCA
TCTCGCCGCCGCTACCGGACGCGTGGTCGCATGCCCTTTCATTCCCGGCCGCGTGCCCGACGACGCGATGGCAATGGTCG
TTGCGGTTCGGCAGCCTGAAGGCACGCTTTTGCCGGAACTTGTGCAGTGGCTCCCACTGTCTGCGCTTGACGAGCCGATT
GGTGCCGTCGGCGCGGCGGCCCTGCGCGAGACCACGACGATCGTGACTGCTCTTATCTCTTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6787.78 Da
• Isoelectric Point: 3.9020

>AT141561 WP_060555126.1 NZ_CP045257:3394691-3394879 [Proteus mirabilis]
MNTVQIPTGSIKTFGLFGIPYEVGEPAQELPDGDILVNIILVQTGEKELYKLSKLLQDPDAE

Nucleotide

• Length: 189 bp

>AT141561 NZ_CP060015:2066362-2066589 [Mycobacterium malmoense]
ATGGCGAAGCGGAAGATTTCAGTGACGGTCGACGCGCACATTCTCGCCGCAACCGACGCAAACGCCAGGTCCGCCGGGTT
GAATCGCTCGGAGATGATCGAACAAGCTCTACGCAACGAGCATCTGCGTATCGCCCTGCACAACTACACGAACCGCACCG
TTCCGGCGCTGGACATCGACGCGTACGCGCAGAACGTATATCGGGCGAACCGATCCTCCGGCCTGTGA