Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 3356537..3358259 Replicon chromosome
Accession NZ_CP045257
Organism Proteus mirabilis strain L90-1

Toxin (Protein)


Gene name mosT Uniprot ID D0FZT9
Locus tag GCE56_RS16315 Protein ID WP_000356587.1
Coordinates 3356537..3357475 (-) Length 313 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A1U9VYW4
Locus tag GCE56_RS16320 Protein ID WP_000095578.1
Coordinates 3357468..3358259 (-) Length 264 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE56_RS16295 3352478..3352990 - 513 WP_024008829.1 S26 family signal peptidase -
GCE56_RS16300 3352974..3353321 - 348 WP_024008830.1 hypothetical protein -
GCE56_RS16305 3353314..3355713 - 2400 WP_024008831.1 type IV secretion system protein TraC -
GCE56_RS16310 3355713..3356405 - 693 WP_024008832.1 DsbC family protein -
GCE56_RS16315 3356537..3357475 - 939 WP_000356587.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GCE56_RS16320 3357468..3358259 - 792 WP_000095578.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
GCE56_RS16325 3358480..3358866 - 387 WP_000180225.1 hypothetical protein -
GCE56_RS16330 3358863..3359435 - 573 WP_024008834.1 type IV conjugative transfer system lipoprotein TraV -
GCE56_RS16335 3359510..3360799 - 1290 WP_156868343.1 TraB/VirB10 family protein -
GCE56_RS16340 3360802..3361698 - 897 WP_032194332.1 type-F conjugative transfer system secretin TraK -
GCE56_RS16345 3361682..3362308 - 627 WP_000667167.1 hypothetical protein -
GCE56_RS16350 3362305..3362586 - 282 WP_000433891.1 type IV conjugative transfer system protein TraL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(J) - 3264743..3440274 175531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(99-250)


Sequences

Toxin        


Download         Length: 313 a.a.        Molecular weight: 35548.82 Da        Isoelectric Point: 4.9081

>T141559 WP_000356587.1 NZ_CP045257:c3357475-3356537 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIVVSSPVATIKIEVSPVARGTLHSAEIMPVQESVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE

Download         Length: 939 bp

>T141559 NZ_CP060015:c605932-605687 [Mycobacterium malmoense]
GTGGCGATCACCGCGTCCGAGGCACGCAAGAACTTATTTCCGTTGATCGAGCAGGTCAACAACGACCGCGTCCCGGTGGA
GATCAACTCCCGCCGGGGTGATGCGGTATTGATCTCGCGCGCCGACTACGAAGCCCTGGAAGAGACCGCGCACCTGTTGC
GGTCCCCCGCCAATGCCCGTCGGCTGCTGGAAAGCCTTACCCAGGCGCAGCGTGGCGAACGCGAAGAGCACACGTTGTCC
CGGTGA

Antitoxin


Download         Length: 264 a.a.        Molecular weight: 30095.47 Da        Isoelectric Point: 9.5097

>AT141559 WP_000095578.1 NZ_CP045257:c3358259-3357468 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRVDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Download         Length: 792 bp

>AT141559 NZ_CP060015:c605690-605433 [Mycobacterium malmoense]
GTGAGGCTGGTCTTCACGCCTCTCGGATGGGCCGACTACCAGTACTGGAGCACAACCGACCGAGGGACACAGAAGCGTAT
CAACCGCCTCATCGATGACACCTTGCGTGATCCGTTCGCCGGGATTGGCAAACTTGAGCCGTTACGCCACGCCTTCGCGG
GCGCCTGGTCACGGCGCATCAGCGAGGAACACCGCTTGGTGTACCTCGTCGATGGCGATGACGTCGTGATCGTGCAGGCC
CGGTACCACTACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9VZ44

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9VYW4

References