Detailed information of TA system TA141557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1755240..1756039
• Replicon: chromosome
• Accession: NZ_CP045257
• Organism: Proteus mirabilis strain L90-1

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: A0A8E3RD10
• Locus tag: GCE56_RS08865
• Protein ID: WP_004247966.1
• Coordinates: 1755515..1756039 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: B4EVS2
• Locus tag: GCE56_RS08860
• Protein ID: WP_004247964.1
• Coordinates: 1755240..1755518 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE56_RS08835	1750590..1751672	+	1083	WP_004242680.1	peptide chain release factor 1	-
GCE56_RS08840	1751672..1752520	+	849	WP_004247962.1	peptide chain release factor N(5)-glutamine methyltransferase	-
GCE56_RS08845	1752498..1753313	+	816	WP_004242688.1	invasion regulator SirB1	-
GCE56_RS08850	1753371..1754225	+	855	WP_004242689.1	3-deoxy-8-phosphooctulonate synthase	-
GCE56_RS08855	1754233..1755162	+	930	WP_017628160.1	TIGR01212 family radical SAM protein	-
GCE56_RS08860	1755240..1755518	+	279	WP_004247964.1	DUF1778 domain-containing protein	Antitoxin
GCE56_RS08865	1755515..1756039	+	525	WP_004247966.1	hypothetical protein	Toxin
GCE56_RS08870	1756120..1757820	-	1701	WP_017628159.1	C4-dicarboxylic acid transporter DauA	-
GCE56_RS08880	1758784..1759725	+	942	WP_004242695.1	glyoxylate/hydroxypyruvate reductase GhrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (5-87)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 19192.12 Da
• Isoelectric Point: 9.3561

>T141557 WP_004247966.1 NZ_CP045257:1755515-1756039 [Proteus mirabilis]
MTIPNWHEEAISKKHNRNGFNCGDAVLNQFLYRHARQNHENGSAKTYLAINNSNNIILGYYSLCPASIEFERTPELIKHG
LARHDIPVFKLARLATDLSVQGKGLGGQLLLAAGRRCLSVASELGGVALLIDAKNERVANWYISYGAIPLLDTPLSLLIS
FKTIYTALSMANKI

Nucleotide

• Length: 525 bp

>T141557 NZ_CP060015:573126-574010 [Mycobacterium malmoense]
GTGGCCGGCCTTACCCGCGCCCTAGTCGCACGTCATGCGGCTGGACGAGCCGATGCATACGATGCAGCGTTGCTCGACGT
CGCCCAAGATCACCTGCTTTTCCTCCTTGCCCAAGCGGCGAACATCGGTGACGGTCGGCTGGTATTTAAGGGTGGCACTA
GCTTGCGGAAGTGTCGGTTAGGCAACGCTGGCCGATTCTCAATCGACTTAGATTTCGGCGCGCCCGACGACGACGTAGTG
CTCGAGGTCTGCGGCCTTATCGATGGAGCCCGCATCGGTGGCTTTGAATTTGGCATCGTGAGCACCAGGGGTGATGGACG
TCATTGGGGGCTGACGGTCAGTCATGCTGAACTGGGCGCGCCCCGGATTGCAGCCAGTGTCGAATTCGCACGGCGCCCGT
TGGCTCTACCGCCGGAGCCGCTCCCTTTTGTGCCGTTGCCGATCCATAGGGCCTACGGCTTTCCCTTGCCGACGCTGCCA
GTGGTCGCTGAAGCGGAAGCTTGCGCAGAAAAACTTGCGCGATACCGACGCGTCGCTTTGGCACGAGATCTCTACGACTT
GAACCATTTCGCGACTCGCACTTTCGACGAACCTCTTGTGCGGCGCTTATGGGTACTCAAGGTGTGGGCCGACGTGGTTG
ACGATCGACGTGGCGGCCGCCCTCTTCGGCCAGAAGACATCCTCACTGTCCGTGGTGAACAAGACTTCGAGCCCGACTCG
ATTGGGATTTTGACACGGCCCGTCGACATCCCGGACTGGGAAGCCCGCGTTCGACGTCGGTTCGCGTTCCTCACCGACCT
CGACGCGAACGAACAGCGGTGGGCTTCCTGCAACGAACGTCACCGATCGGAAGTGCAAGACGCGCTCTCCGCGCTGCGCG
GTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10252.82 Da
• Isoelectric Point: 5.1369

>AT141557 WP_004247964.1 NZ_CP045257:1755240-1755518 [Proteus mirabilis]
MAQALVENSERVSIRITTEDKSLLVRAASLENTNLTEFVLRNIVPVARQVIENNERLKLSEKDTLRVMELLDNPPKPNAK
LLAAAFALPDNA

Nucleotide

• Length: 279 bp

>AT141557 NZ_CP060015:572209-573123 [Mycobacterium malmoense]
ATGAACCTAAGCGCGCATGGTGCAACCAGTCCCTTGGGTGCCGACCGGCGCATCCCAAAGTGGGCCTCGGCGGTGATTGG
CGGGCTTGCTCGCGATCGACCGATCGTCGTGACGACCGAAGATCTCGCCCTACGGCTAGCGGAAGCCACCAGTGAGCGCG
ATGTCGATTTAGCAATACGCGACCTACGGCGCCTGGGCTGGCTGGTCGGCCTGCCGGTGCGAGGAACTTGGGCATTCATC
CCGCCAGGAGAGGCTGGCGTGTCCGACCCGTATCTTCCGGTCCGTGCATGGCTAGCGCGTGATCACGACGCAGGCTGCAT
GCTGGCCGGTGCCGCAGCTGCGTGGCATCTCGGGTACCTGGATCGGCAGCCTCAGGGTCGAGTTTCACTGTGGCTTCCAG
CCAAGACGCGACTTCCAGACGGTCTGCGCAAATACGTGTCAATTGTGAAAATCTCCTGGAATATCCAGGACGCTGCGCAG
CTGGCCCCGAGCACGGCGCTGCTCCTCAGACGGCGGCTCGATATCGTGTCGTGGGCGACAGGACTACCCGCGTTTGGCCC
GGAGGCACTGCTTGTGCAGCTCGCCGCGCGCCCATCATCGTTCAGACCATGGGCAGATATCGTCGCGCACCTGGACGTGC
TAGCTGCTGATTGCGTCGATGAGCACCTGCTACCACTTCTTTCGGGCCAGTCGATGTCGACATGGCAACGCGCAAGCTAC
CTGATCGACGTGGCAGGTGACCCTGAACGAGGCGCGGCGCTGCTCGCAAAACGTCAGATGAAGACGATGTCCGTCGTGCA
ATTCACTCATCCGCACATTCGGGCGAGTCGCAGCACCGAGGGCGTCTGGGTTCCGAAATACCAGCTCGTCGATGGTCTCG
TCGCACCGTTGTTATCCGTTGTTGGCAAGGCCTGA

Structures

Antitoxin

• AlphaFold DB: B4EVS2