Detailed information of TA system TA141556

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1517579..1518224
• Replicon: chromosome
• Accession: NZ_CP045257
• Organism: Proteus mirabilis strain L90-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: B4ET86
• Locus tag: GCE56_RS07645
• Protein ID: WP_004247035.1
• Coordinates: 1518039..1518224 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B4ET85
• Locus tag: GCE56_RS07640
• Protein ID: WP_004247034.1
• Coordinates: 1517579..1517992 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GCE56_RS07610	1513132..1513290	-	159	WP_004247025.1	hypothetical protein	-
GCE56_RS07615	1513742..1513918	+	177	WP_004247793.1	hypothetical protein	-
GCE56_RS07620	1514089..1514835	-	747	WP_017628402.1	methyltransferase domain-containing protein	-
GCE56_RS07625	1515685..1516263	+	579	WP_017628400.1	alpha/beta hydrolase	-
GCE56_RS07630	1516376..1516669	-	294	Protein_1396	LysE family transporter	-
GCE56_RS07635	1516983..1517483	-	501	WP_004247032.1	response regulator	-
GCE56_RS07640	1517579..1517992	-	414	WP_004247034.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GCE56_RS07645	1518039..1518224	-	186	WP_004247035.1	type II toxin-antitoxin system HicA family toxin	Toxin
GCE56_RS07650	1518335..1519105	+	771	Protein_1400	DUF1073 domain-containing protein	-
GCE56_RS07655	1519664..1520215	-	552	WP_017628396.1	PH domain-containing protein	-
GCE56_RS07660	1520279..1520593	-	315	WP_017628395.1	hypothetical protein	-
GCE56_RS07670	1521000..1522733	-	1734	WP_017628394.1	LPS biosynthesis-modulating metalloenzyme YejM	-
GCE56_RS07675	1522757..1522984	-	228	WP_004247042.1	YejL family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1512349..1530206	17857

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 7049.30 Da
• Isoelectric Point: 10.9659

>T141556 WP_004247035.1 NZ_CP045257:c1518224-1518039 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN

Nucleotide

• Length: 186 bp

>T141556 NZ_CP060015:c111403-111011 [Mycobacterium malmoense]
ATGATCTTCGTTGACACATCCTTCTGGGCTGCACTCGGCAATGCCACAGACGCCCACCACACGGCTGCCGAGAGGCTCTG
GGCCGCCAAACCGCCCTTCGTCGTGACCTCGAACCATGTCCTGGGCGAAACGTGGACACTGCTCAACCGGCGCTGCGGTC
ATCGGGTCGCGGTGACTGCCGCGGCCATTCGCTACAGCAGTCACGTCCGGCTCGAACACATTACGGCCGAGCTGGAGGAA
GAAGCGTGGGAATGGCTTGCCCGGCATGACGAGCGGGAGTATTCGTTCGTCGACGCCACGAGTTTCGCGCTGATGCGCAA
GAAGAAGCTTCGCGATGCCTATGCGTTCGATGAAGATTTCAGCGCAGCCGGATTTGTTGAGCTGAGACCCTAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15251.98 Da
• Isoelectric Point: 4.3830

>AT141556 WP_004247034.1 NZ_CP045257:c1517992-1517579 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI

Nucleotide

• Length: 414 bp

>AT141556 NZ_CP060015:c111621-111400 [Mycobacterium malmoense]
ATGAAGCGGCTGCAGATCTACATAGAGGAAGACCTGGATCACGCGCTTGGCATCGAAGCTCGCCGGCAGCGCAAATCGAA
GGCCGCGCTCATCAGGGCGTACGTAGCTGATCGTCTTGGCGCGCGTGAACCAGATCCGATCGATGCCTTCATCGGATCGT
TCGACGGGGGAGTCGACTTGTCCACGTCCGTCGATGACGTGGTCTACGGACCACGTGAATGA

Structures

Toxin

• AlphaFold DB: B4ET86

Antitoxin

• AlphaFold DB: B4ET85