Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 13291..13892 Replicon chromosome
Accession NZ_CP045257
Organism Proteus mirabilis strain L90-1

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag GCE56_RS00430 Protein ID WP_036895893.1
Coordinates 13291..13674 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag GCE56_RS00435 Protein ID WP_004246496.1
Coordinates 13671..13892 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCE56_RS00405 8355..9842 - 1488 WP_087726303.1 PLP-dependent aminotransferase family protein -
GCE56_RS00410 9971..10429 + 459 Protein_7 GNAT family N-acetyltransferase -
GCE56_RS00415 10525..11262 - 738 WP_004249950.1 sel1 repeat family protein -
GCE56_RS00420 11371..12270 + 900 WP_017826985.1 N-acetylmuramic acid 6-phosphate etherase -
GCE56_RS00425 12570..12884 - 315 WP_004246498.1 helix-turn-helix domain-containing protein -
GCE56_RS00430 13291..13674 - 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GCE56_RS00435 13671..13892 - 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GCE56_RS00440 14173..15036 - 864 WP_004249947.1 YicC family protein -
GCE56_RS00445 15163..15879 + 717 WP_004249760.1 ribonuclease PH -
GCE56_RS00450 15961..16605 + 645 WP_004246493.1 orotate phosphoribosyltransferase -
GCE56_RS00455 16924..17529 - 606 WP_004246491.1 nucleoid occlusion factor SlmA -
GCE56_RS00460 17649..18107 - 459 WP_004246490.1 dUTP diphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T141555 WP_036895893.1 NZ_CP045257:c13674-13291 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T141555 NZ_CP060015:68623-68928 [Mycobacterium malmoense]
ATGAGCCGGCATGTACTTTCACCTGCCGCACATGCCGACTTGGAACAGATCTGGGACTACACCTGTGAGCGCTGGGATGA
CGATCAAGCCGAAGAATACGTGCGTGAAATCCAGCGTGCGATCGACCGGGTCGTGGACAATCCGATGATCGGACGGGCGT
GCGACGAAGTCCGGCCCGGATACCGGAAGCACACGGTCGGGTCGCACACACTGTACTGCCGGATCGCGCGCGGCGACGTG
ATCGATGTGGTGCGCATACTCCACCAACGGATGGATGTCGATCGACACCTCGATTCAGGCATGTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT141555 WP_004246496.1 NZ_CP045257:c13892-13671 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT141555 NZ_CP060015:68375-68626 [Mycobacterium malmoense]
GTGGGTAGGAACACGTCATTCAGCCTCGATGACCATCACAGAGCCTTCATCGAGCAGGAGGTCGCCTCGGGCCGTTACCG
GTCGGCCAGCGATGTCGTGCGTTCTGCTCTGCGGTTGCTTGAAGATCGTGAGACTCGGTTGAGCGCATTGCGCCAGGCAC
TTGTCACTGGCGAACAAAGCGGCGAGTCGAGACCGTTCGACTTCGACGAGTTCGTTGCGCGCAAGCGAGGCGAAAACTCT
CGCCGCCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References