Detailed information of TA system TA141544

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1461434..1462074
• Replicon: chromosome
• Accession: NZ_CP045236
• Organism: Burkholderia cepacia strain BC16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BURCE16_RS23540
• Protein ID: WP_059683063.1
• Coordinates: 1461434..1461835 (-)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: -
• Locus tag: BURCE16_RS23545
• Protein ID: WP_048025990.1
• Coordinates: 1461832..1462074 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BURCE16_RS23530	1459174..1460904	-	1731	WP_059683067.1	cation acetate symporter	-
BURCE16_RS23535	1460901..1461209	-	309	WP_059683065.1	DUF485 domain-containing protein	-
BURCE16_RS23540	1461434..1461835	-	402	WP_059683063.1	type II toxin-antitoxin system VapC family toxin	Toxin
BURCE16_RS23545	1461832..1462074	-	243	WP_048025990.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BURCE16_RS23550	1462335..1463018	+	684	WP_153489735.1	phospholipase	-
BURCE16_RS23555	1463069..1464580	-	1512	WP_153489736.1	amino acid permease	-
BURCE16_RS23560	1464687..1466093	-	1407	WP_027791265.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14582.71 Da
• Isoelectric Point: 6.3298

>T141544 WP_059683063.1 NZ_CP045236:c1461835-1461434 [Burkholderia cepacia]
MKFLLDTNAVIAILKGEPAILSRLRSHQPGDFGIPAIVAHELYYGAYKSQRVAANVARVEALQFEVVSFDVEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLITHDIREFERVPRLQVEDWLAGAS

Nucleotide

• Length: 402 bp

>T141544 NZ_CP060008:2435442-2436011 [Pseudomonas sp. B11D7D]
ATGTTCAAGCCGCAGCTGGTGACTCTGCAACGTGGCGCGTTGCGCCTGGAACCGCTTTCTGACGCGGATATCCCCGCCCT
GGTGGCGCTGGCCGAGGCCAATCGTGAGGAGCTGCTGTACATGAGCGGCACCCAGCGACTGGATTGGTACCGCAGCGCCC
TGGCCGATCTGCGCGAGCAGCGGGCCTTGCCGTTCGTCATTCGTCTGGGTGACGAACTGGTGGGCACCACGCGCTTTGCC
GATTTCATAAACAACCTGCCAGCCTGCGAAATCGGCTGGACCTGGCTCGACCGCAATCAACACGGCAGCGGACTGAACAC
CACCATCAAGTACCTGATGCTCAGGCATGCGTTCGATAACTGGGGCATGGTGCGTGTACAGCTCAAAACCGCTGCCAGTA
ACCTGCGCTCGCAACGCGCCATCGAGAAGCTCGGTGCCGTCCGTGAAGGTTTGCTGCGCAACCATCGCCGCCTGGCTGAT
GGTCGTCTCGATGACACCGTGCTGTACAGCATCACCGACCTGGAGTGGCCAGCGTTGCGTGAGGCGATGGAGGCTGGCTT
CAACGCCTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8945.09 Da
• Isoelectric Point: 4.7335

>AT141544 WP_048025990.1 NZ_CP045236:c1462074-1461832 [Burkholderia cepacia]
MDIAKIFKHGGSQAVRLPKDFRFDTAEVRIRRHGSSVVLEPVPQDWAWLTPLIGPVDADFEAAATTQPSAQERPDLDVFE

Nucleotide

• Length: 243 bp

>AT141544 NZ_CP060008:2436017-2436844 [Pseudomonas sp. B11D7D]
ATGCACAGCCGCGAGCAGACCCGCTTCTGGCAAGCCTCCGCATTGAGCGGCGTCGAATTGTTGCAGGCGCGCTACCTCGA
GCAGCGCTTCGCGCCGCACGTGCATGAAGGGTTCGTCTTCACCGTGATCGAACATGGTGCCCAGCGCTTTCGCCACCGTG
GCAGCGATCACTTGGCGCCGCAGGGCAGCATGGTGCTGATCAACCCGGACGAAGTGCACACCGGCTCCAAGGCGCACGAA
GACGGTTGGCGCTATCGCGGTTTCTATCCCGACAATTCCCAGGTACTGGGTGCACTGCAGGAACTGGGGTTGGCCAAGAC
CGGCATGCCGTCATTTTCCTTCAGCGTGCTGCATGATCCGCGTCTGCACGCCGCCTTTCTGCACCTGCACCAGTTGCTCG
AACACGGCGCCGAGGCGTTGCAGCAGCAACTGGCCTGGCGTGAGGCGATCCTGCTGCTGTTCCAGCACCATGCACAGCTT
GCCGAACCGCCCGCGCCTGGGCGCGAGCCCTGGGCTGTGGCCTGCGCCAAGCAGATGCTGGCCGAGCGCCTGGTCGAGCC
GCCTTCGCTGGAGGAACTGGCGGCAGCGGTCAATCTTTCACCTTTTCACTTCGCGCGGGTATTTCGTCGTGCGACGGGGC
TGCCACCGCATGCCTGGCTCAAGCAGCGACGCCTGGAACAGGCGCGGGCCTTGCTCAAGAGTGGCTGCACGGCGGTCAGC
GTGGCCATGCAGCTGGGTTTCGCCGATCAGAGCCACCTGTCGCGACAGTTCAAGCAGGTTTATGGCGTCAGTCCCGGTGA
GTATCGCAGCGGCGTGGCGCGGATGTAG