Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 538769..540519 Replicon chromosome
Accession NZ_CP045236
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BURCE16_RS19590 Protein ID WP_153489287.1
Coordinates 538769..539665 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag BURCE16_RS19595 Protein ID WP_153489288.1
Coordinates 539662..540519 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS19555 534146..535225 - 1080 WP_042976372.1 porin -
BURCE16_RS19560 535250..535576 + 327 WP_153489285.1 hypothetical protein -
BURCE16_RS19565 535671..535988 + 318 WP_153489286.1 non-heme iron oxygenase ferredoxin subunit -
BURCE16_RS19570 535990..536301 + 312 WP_059686077.1 hypothetical protein -
BURCE16_RS19575 536356..537426 + 1071 WP_059697603.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BURCE16_RS19580 537419..538189 + 771 WP_048022637.1 SDR family oxidoreductase -
BURCE16_RS19585 538223..538750 + 528 WP_021161513.1 cupin domain-containing protein -
BURCE16_RS19590 538769..539665 + 897 WP_153489287.1 alpha/beta fold hydrolase Toxin
BURCE16_RS19595 539662..540519 + 858 WP_153489288.1 IclR family transcriptional regulator Antitoxin
BURCE16_RS19600 540516..541313 + 798 WP_153489289.1 SDR family oxidoreductase -
BURCE16_RS19605 541306..542973 + 1668 WP_027789377.1 thiamine pyrophosphate-binding protein -
BURCE16_RS19610 542966..543793 + 828 WP_153489290.1 aspartate dehydrogenase -
BURCE16_RS19615 543866..545356 + 1491 WP_059686086.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-277)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30591.77 Da        Isoelectric Point: 7.7327

>T141540 WP_153489287.1 NZ_CP045236:538769-539665 [Burkholderia cepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVSQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIVAGGLARVMPARIAGLLLVSPAGGYGSAPAETR
ESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEARAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPSVYSALIDSFCRQCDQQRGLA

Download         Length: 897 bp

>T141540 NZ_CP060002:5117915-5118331 [Xanthomonas citri pv. citri]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31532.06 Da        Isoelectric Point: 6.6569

>AT141540 WP_153489288.1 NZ_CP045236:539662-540519 [Burkholderia cepacia]
MNEPLQRPEPENDKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELRSLYPEGTLNRMTNATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFMKALGLR

Download         Length: 858 bp

>AT141540 NZ_CP060002:5117664-5117918 [Xanthomonas citri pv. citri]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References