Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 359489..360144 Replicon chromosome
Accession NZ_CP045236
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name vapC Uniprot ID U2HGC0
Locus tag BURCE16_RS18785 Protein ID WP_021158162.1
Coordinates 359725..360144 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2HMP5
Locus tag BURCE16_RS18780 Protein ID WP_021158161.1
Coordinates 359489..359728 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS18755 354762..355157 - 396 WP_042973908.1 type II toxin-antitoxin system VapC family toxin -
BURCE16_RS18760 355154..355393 - 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BURCE16_RS18765 355481..356164 - 684 WP_021158158.1 Fe2+-dependent dioxygenase -
BURCE16_RS18770 356161..356928 - 768 WP_060066503.1 sel1 repeat family protein -
BURCE16_RS18775 356932..359178 - 2247 WP_153489213.1 TonB-dependent siderophore receptor -
BURCE16_RS18780 359489..359728 + 240 WP_021158161.1 antitoxin VapB Antitoxin
BURCE16_RS18785 359725..360144 + 420 WP_021158162.1 type II toxin-antitoxin system VapC family toxin Toxin
BURCE16_RS18790 360280..361575 - 1296 WP_027789492.1 aspartate carbamoyltransferase -
BURCE16_RS18795 361809..361943 + 135 WP_021158165.1 entericidin A/B family lipoprotein -
BURCE16_RS18800 362032..362581 - 550 Protein_319 permease -
BURCE16_RS18805 362765..363718 - 954 WP_153489214.1 DMT family transporter -
BURCE16_RS18815 364052..364846 - 795 WP_153489215.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15212.57 Da        Isoelectric Point: 5.9052

>T141539 WP_021158162.1 NZ_CP045236:359725-360144 [Burkholderia cepacia]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Download         Length: 420 bp

>T141539 NZ_CP060002:c4720130-4719978 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8629.79 Da        Isoelectric Point: 5.6643

>AT141539 WP_021158161.1 NZ_CP045236:359489-359728 [Burkholderia cepacia]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Download         Length: 240 bp

>AT141539 NZ_CP060002:c4719903-4719769 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2HGC0

Antitoxin

Source ID Structure
AlphaFold DB U2HMP5

References