Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 192092..193313 Replicon chromosome
Accession NZ_CP045236
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BURCE16_RS18035 Protein ID WP_111939342.1
Coordinates 192092..192673 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BURCE16_RS18040 Protein ID WP_153489147.1
Coordinates 192756..193313 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS18020 187765..189825 - 2061 WP_153489142.1 MacB family efflux pump subunit -
BURCE16_RS18025 189828..191021 - 1194 WP_153489144.1 macrolide transporter subunit MacA -
BURCE16_RS18030 191308..192036 - 729 WP_153489145.1 class I SAM-dependent methyltransferase -
BURCE16_RS18035 192092..192673 - 582 WP_111939342.1 HD domain-containing protein Toxin
BURCE16_RS18040 192756..193313 - 558 WP_153489147.1 helix-turn-helix domain-containing protein Antitoxin
BURCE16_RS18045 193398..194036 - 639 WP_153489149.1 hypothetical protein -
BURCE16_RS18050 194398..195801 + 1404 WP_059484040.1 hypothetical protein -
BURCE16_RS18055 195898..196476 + 579 WP_153489151.1 hypothetical protein -
BURCE16_RS18060 196558..196947 - 390 WP_153489152.1 OsmC family protein -
BURCE16_RS18065 197178..197909 + 732 WP_111939346.1 ribonuclease T2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-173)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21273.85 Da        Isoelectric Point: 5.0928

>T141538 WP_111939342.1 NZ_CP045236:c192673-192092 [Burkholderia cepacia]
MNPDTIHARLAFLREAERLKDVLRSGHTSAGRAESTAEHSWRLCLMALVFADALPGIDTLKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTAPLDPARRDEIVALWDEYEAAASPEARAAKAFDKLETILQHTQGSNPPDFDYAFNLGY
GRRYTDAAPLFSAIRDIVDADTQRRIDASGQHA

Download         Length: 582 bp

>T141538 NZ_CP060002:c4719903-4719769 [Xanthomonas citri pv. citri]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGATGTTGTCGGTGGGAATGCTGGCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20039.02 Da        Isoelectric Point: 10.7174

>AT141538 WP_153489147.1 NZ_CP045236:c193313-192756 [Burkholderia cepacia]
MSASPLHAPPLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPGERATAERLLAARLDSAGDHALARLVAG
SAGRMHLVCDLTHRLLTCSPARAAEFSQPLSMLLGTSLWRYATPAIVRMETALDTLGWHDRAGPPSVEFDTGANASRVVP
IRGSLCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT141538 NZ_CP060002:c4720130-4719978 [Xanthomonas citri pv. citri]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCCGGCGC
CGGCAAGGACATGCAGGGTGCGGGCAACAAGGTCGAGAAAACGGCCGAAAAATGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References