Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1819840..1820513 Replicon chromosome
Accession NZ_CP045235
Organism Burkholderia cepacia strain BC16

Toxin (Protein)


Gene name vagD Uniprot ID U2G353
Locus tag BURCE16_RS08390 Protein ID WP_021160096.1
Coordinates 1820097..1820513 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A4S5D574
Locus tag BURCE16_RS08385 Protein ID WP_049096496.1
Coordinates 1819840..1820100 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BURCE16_RS08370 1815395..1817647 + 2253 WP_153488288.1 TonB-dependent siderophore receptor -
BURCE16_RS08375 1817734..1818573 + 840 WP_042975471.1 N(5)-hydroxyornithine transformylase PvdF -
BURCE16_RS08380 1818573..1819589 + 1017 WP_059682659.1 acetyltransferase -
BURCE16_RS08385 1819840..1820100 + 261 WP_049096496.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BURCE16_RS08390 1820097..1820513 + 417 WP_021160096.1 PIN domain-containing protein Toxin
BURCE16_RS08395 1820562..1821467 - 906 WP_153488290.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
BURCE16_RS08400 1821436..1822509 - 1074 WP_153488292.1 hypothetical protein -
BURCE16_RS08405 1822851..1824014 + 1164 WP_027787433.1 amidohydrolase -
BURCE16_RS08410 1824258..1824797 + 540 WP_059623530.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T141537 WP_021160096.1 NZ_CP045235:1820097-1820513 [Burkholderia cepacia]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

>T141537 NZ_CP060002:c2886215-2885964 [Xanthomonas citri pv. citri]
ATGCAACGGCTGCGCGAATTCCTGAAGCCGAAGAGTCCCGATGCCGCGAGGCGGGCCGGTGAAGCGATTAGGCGCGGCGT
CCAGGCTCTCGGTGCCCACCCTCGAATGGGGCGGCTCATAGAAGATCTGCCTGAACAGTATCGGGAGTGGCTTATCGATT
TTGGGGATAGTGGCTATGTGGCTCGGTACCGCCACGCTGGCGATACCGTCACGATTTTGGCCGTGCGACACCAGAAGGAA
GCGGGGTACTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9564.84 Da        Isoelectric Point: 4.6151

>AT141537 WP_049096496.1 NZ_CP045235:1819840-1820100 [Burkholderia cepacia]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLMLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp

>AT141537 NZ_CP060002:c2886520-2886242 [Xanthomonas citri pv. citri]
ATGGTTACGGCAACTTCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCGCGCCGGCGTAC
CCCGCATTGGATCATGCGCGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGTGAGGCGTTGAACCGGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACGGGCCTGCACGTGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGCTGGGGA
ACAGACGACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G353

Antitoxin

Source ID Structure
AlphaFold DB A0A4S5D574

References