Detailed information of TA system TA141528

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 676674..677287
• Replicon: chromosome
• Accession: NZ_CP045226
• Organism: Nostoc sphaeroides CCNUC1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GXM_RS03005
• Protein ID: WP_152588182.1
• Coordinates: 676901..677287 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: GXM_RS03000
• Protein ID: WP_118164132.1
• Coordinates: 676674..676919 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GXM_RS02955	671854..672066	+	213	WP_118164156.1	hypothetical protein	-
GXM_RS02960	672084..672509	+	426	WP_152588175.1	type II toxin-antitoxin system VapC family toxin	-
GXM_RS02965	672556..672762	+	207	WP_152588176.1	type II toxin-antitoxin system HicB family antitoxin	-
GXM_RS02970	672759..672980	+	222	WP_152588177.1	type II toxin-antitoxin system HicA family toxin	-
GXM_RS02975	673144..673374	+	231	WP_152588178.1	hypothetical protein	-
GXM_RS02980	673371..673640	+	270	WP_152588179.1	hypothetical protein	-
GXM_RS02985	673748..674308	+	561	WP_152588180.1	Uma2 family endonuclease	-
GXM_RS43195	675183..675347	-	165	WP_181985078.1	hypothetical protein	-
GXM_RS43200	675344..675490	-	147	WP_194198704.1	hypothetical protein	-
GXM_RS02995	675500..676195	-	696	WP_152588181.1	calcium-binding protein	-
GXM_RS03000	676674..676919	+	246	WP_118164132.1	DUF2281 domain-containing protein	Antitoxin
GXM_RS03005	676901..677287	+	387	WP_152588182.1	type II toxin-antitoxin system VapC family toxin	Toxin
GXM_RS03010	677354..677935	+	582	WP_118164127.1	Uma2 family endonuclease	-
GXM_RS03015	677940..678134	+	195	WP_118164124.1	hypothetical protein	-
GXM_RS03020	678212..678766	+	555	WP_152588183.1	Uma2 family endonuclease	-
GXM_RS03025	678898..679479	+	582	WP_152588184.1	YdcF family protein	-
GXM_RS03030	679517..680299	-	783	WP_152588185.1	class I SAM-dependent methyltransferase	-
GXM_RS03035	680329..681402	-	1074	WP_152588186.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• VapC-like Sll0205 protein, PIN domain (5-127)

Antitoxin

• Domain of unknown function DUF2281 (6-74)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14539.81 Da
• Isoelectric Point: 4.8214

>T141528 WP_152588182.1 NZ_CP045226:676901-677287 [Nostoc sphaeroides CCNUC1]
ISAFLLDTHAFIWLTENDSSLPENLRMMINSADIVYLSIASLWEIAIKLNLGKLSLQRSYETIGSAIDASDILILPISFA
DTVQVRNLPLHHGDPFDRMLIAQAMNHSLIIINRDKKLDAYSVERMWE

Nucleotide

• Length: 387 bp

>T141528 NZ_CP060000:c6101-5769 [Xanthomonas citri pv. citri]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9420.86 Da
• Isoelectric Point: 4.3085

>AT141528 WP_118164132.1 NZ_CP045226:676674-676919 [Nostoc sphaeroides CCNUC1]
MAIDAEILQTLDQMPEPLKQELLHYAKYLVENYSKAISQESILQQKRRSGILKGTFVLPLPDDFDEPLEVFKEYMESVLS
F

Nucleotide

• Length: 246 bp

>AT141528 NZ_CP060000:c6358-6101 [Xanthomonas citri pv. citri]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA