Detailed information of TA system TA141522

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 6256630..6257300
• Replicon: chromosome
• Accession: NZ_CP045221
• Organism: Pseudomonas chlororaphis subsp. aurantiaca strain ARS 38

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A8A9Z8F6
• Locus tag: FD951_RS28405
• Protein ID: WP_023970008.1
• Coordinates: 6256630..6257058 (-)
• Length: 143 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FD951_RS28410
• Protein ID: WP_023970009.1
• Coordinates: 6257055..6257300 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FD951_RS28375	6251855..6252343	-	489	WP_023970004.1	DoxX family protein	-
FD951_RS28380	6252382..6253122	-	741	WP_023970005.1	SDR family oxidoreductase	-
FD951_RS28385	6253262..6254152	+	891	WP_023970006.1	LysR family transcriptional regulator	-
FD951_RS28390	6254277..6254458	+	182	Protein_5539	type II toxin-antitoxin system HicA family toxin	-
FD951_RS28395	6254488..6254889	+	402	WP_009046450.1	type II toxin-antitoxin system HicB family antitoxin	-
FD951_RS28400	6255463..6256500	+	1038	WP_023970007.1	L-glyceraldehyde 3-phosphate reductase	-
FD951_RS28405	6256630..6257058	-	429	WP_023970008.1	type II toxin-antitoxin system VapC family toxin	Toxin
FD951_RS28410	6257055..6257300	-	246	WP_023970009.1	plasmid stabilization protein	Antitoxin
FD951_RS28415	6257440..6258279	-	840	WP_023970010.1	taurine dioxygenase	-
FD951_RS28420	6258364..6259203	-	840	WP_023970011.1	taurine ABC transporter permease TauC	-
FD951_RS28425	6259200..6259994	-	795	WP_023970012.1	taurine ABC transporter ATP-binding subunit	-
FD951_RS28430	6260089..6261066	-	978	WP_023970013.1	taurine ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 143 a.a.
• Molecular weight: 15853.36 Da
• Isoelectric Point: 5.4927

>T141522 WP_023970008.1 NZ_CP045221:c6257058-6256630 [Pseudomonas chlororaphis subsp. aurantiaca]
MIVLDTNVLSELMRPQPDASVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQTLHASALAMFEEDFIDRIVPFGT
QAALYYAHLVSHRERSGQPINLVDAQIAAICRVHDAAIATRNTKDFTDTGLIVINPWLPLEV

Nucleotide

• Length: 429 bp

>T141522 NZ_CP059999:99659-99958 [Xanthomonas citri pv. citri]
ATGGCTGAAATAATCTGGTCGGTGCCGGCATTGGCTGATCTGGACGCAATTGCCGACTACATCGCAATCGATAACGCACC
CGCTGCAGCGGCGCTGGTGAAACGGGTGTTCGGGCACGTTGAGCAATTGATCGAACACCCGGACAGCGGAAGCCGACCAC
AGGAACTCAAGCGCTCGCGCTATCGCCAGATTGTCGAACCACCTTGCCGCGTGTTCTACCGCGTGGATGGGCAGCGCATC
GTGGTGGTGCACGTCATGCGGTCGGAGCGCGCGCTTCGCGGGAACCGTCTTTCACGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9084.27 Da
• Isoelectric Point: 6.7287

>AT141522 WP_023970009.1 NZ_CP045221:c6257300-6257055 [Pseudomonas chlororaphis subsp. aurantiaca]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTAASQGLGSRIRARFAEVGAVELELPERTEPPRAADLN
E

Nucleotide

• Length: 246 bp

>AT141522 NZ_CP059999:99414-99671 [Xanthomonas citri pv. citri]
ATGCGCACCGAACTTGTCACCACGCTCAAGCGTCAGGCGACCGAACTCCTTGCAGCTGCAGAGCGCGACAAGGAGCCAAT
CCTGATCACACAGCACGGTTTACCCAGTGCCTATCTGGTGGATGTTGCCAGCTATGAGCGCATGCAGCAGCGCATTGCGC
TCCTCGAAGGAATCGCCCGTGGAGAAATGGCAGTCGCGGAAGGCCGTACGCTGAGCCATGAACAGGCACGGCACCGCATG
GCGCGATGGCTGAAATAA

Structures

Toxin

• AlphaFold DB: A0A8A9Z8F6