Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 2078537..2079114 Replicon chromosome
Accession NZ_CP045216
Organism Pantoea dispersa strain BJQ0007

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GAY20_RS09705 Protein ID WP_058781048.1
Coordinates 2078537..2078869 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A8E1V6C0
Locus tag GAY20_RS09710 Protein ID WP_058770344.1
Coordinates 2078869..2079114 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GAY20_RS09680 2074104..2075285 + 1182 WP_152390903.1 FAD-binding oxidoreductase -
GAY20_RS09685 2075427..2075642 + 216 WP_164861080.1 hypothetical protein -
GAY20_RS09690 2075677..2076384 - 708 WP_021508892.1 phage antirepressor KilAC domain-containing protein -
GAY20_RS09695 2076648..2077841 + 1194 WP_058781047.1 glutathione-dependent formaldehyde dehydrogenase -
GAY20_RS09700 2077881..2078228 - 348 WP_058770346.1 hypothetical protein -
GAY20_RS21530 2078258..2078431 - 174 WP_193718020.1 hypothetical protein -
GAY20_RS09705 2078537..2078869 - 333 WP_058781048.1 endoribonuclease MazF Toxin
GAY20_RS09710 2078869..2079114 - 246 WP_058770344.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GAY20_RS09715 2079214..2080068 - 855 WP_058770343.1 helix-turn-helix transcriptional regulator -
GAY20_RS09720 2080184..2081593 + 1410 WP_058781049.1 MFS transporter -
GAY20_RS09725 2081713..2082795 - 1083 WP_058770341.1 sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC -
GAY20_RS09730 2082799..2083752 - 954 WP_127835008.1 carbohydrate kinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-107)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11995.82 Da        Isoelectric Point: 7.8855

>T141513 WP_058781048.1 NZ_CP045216:c2078869-2078537 [Pantoea dispersa]
MVSRFVPDAGDLIWLDFDPTLGHEQGGHRPAVVLSPFAYNNKVGMLLCVPCTTQVKGYPFEVSLTGSRDSVALADQVTSI
DWRARKVVKKSHVTADELSEIRAKAKALIG

Download         Length: 333 bp

>T141513 NZ_CP059995:5269572-5269919 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACTGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCATCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGTGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8955.25 Da        Isoelectric Point: 4.5580

>AT141513 WP_058770344.1 NZ_CP045216:c2079114-2078869 [Pantoea dispersa]
MTTVTLKKWGNSPSIRIPSSVMQSASLSVDDKLELSVEDGKLILVPLREKVYSLDALLDEITDDNVHDKIDFGPSVGKER
I

Download         Length: 246 bp

>AT141513 NZ_CP059995:5269311-5269562 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References