Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4202742..4203540 | Replicon | chromosome |
| Accession | NZ_CP045213 | ||
| Organism | Escherichia coli strain EH41 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0ZYM8 |
| Locus tag | GC231_RS20600 | Protein ID | WP_000854904.1 |
| Coordinates | 4203163..4203540 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
| Locus tag | GC231_RS20595 | Protein ID | WP_001280952.1 |
| Coordinates | 4202742..4203116 (+) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GC231_RS20565 (4199578) | 4199578..4200033 | + | 456 | WP_000581504.1 | IrmA family protein | - |
| GC231_RS20570 (4200112) | 4200112..4200345 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
| GC231_RS20575 (4200445) | 4200445..4201263 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
| GC231_RS20580 (4201318) | 4201318..4201803 | + | 486 | WP_000849580.1 | antirestriction protein | - |
| GC231_RS20585 (4201819) | 4201819..4202295 | + | 477 | WP_001186726.1 | RadC family protein | - |
| GC231_RS20590 (4202358) | 4202358..4202579 | + | 222 | WP_000692315.1 | DUF987 domain-containing protein | - |
| GC231_RS20595 (4202742) | 4202742..4203116 | + | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GC231_RS20600 (4203163) | 4203163..4203540 | + | 378 | WP_000854904.1 | TA system toxin CbtA family protein | Toxin |
| GC231_RS20605 (4203537) | 4203537..4204025 | + | 489 | WP_000779174.1 | DUF5983 family protein | - |
| GC231_RS20610 (4204037) | 4204037..4204234 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
| GC231_RS20615 (4204319) | 4204319..4205161 | + | 843 | WP_001562462.1 | DUF4942 domain-containing protein | - |
| GC231_RS20620 (4205504) | 4205504..4206040 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
| GC231_RS20625 (4206042) | 4206042..4207220 | - | 1179 | WP_000094989.1 | type II secretion system protein GspL | - |
| GC231_RS20630 (4207217) | 4207217..4208194 | - | 978 | WP_000633239.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 4126052..4265069 | 139017 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14280.26 Da Isoelectric Point: 7.2922
>T141506 WP_000854904.1 NZ_CP045213:4203163-4203540 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T141506 NZ_CP059993:c16624-16292 [Xanthomonas citri]
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA
ATGGATCGCGGCGATGTCTATTTGGTTTCGCTCGATCCCACGTCCGGCCATGAACAACAGGGCACGCGCCCGGTGCTGAT
TGTGTCGCCAAGCGCGTTCAACCGCCTGACGAAAACACCGGTCGTGCTGCCGATCACCAGTGGGGGTAACTTCGCCCGCA
CGGCAGGCTTTACCGTGTCGCTCATGGGTGCGGGTACCAACACAACTGGCGTAGTTCGCTGCGATCAGCCCCGCGCTCTC
GATCTAGCCTCGCGGCGCGCGCGCAAGCTGGAAACCGTGCCGTCCCCGATCATGGATGAGGTATTAGCGAAGCTGAGCGC
GATCCTTGAGTAA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT141506 WP_001280952.1 NZ_CP045213:4202742-4203116 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT141506 NZ_CP059993:c16881-16624 [Xanthomonas citri]
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA
ATGCATACGACCAATCTGCGTAAGGTCGGTGGCTCGATCATGTTGGCTGTCCCGCCCGCCATTCTGGATATGCTGCGTCT
GCGTGCCGGCGCTACCGTTGGCTTGGCCGTCGATCATGGTCGCCTGGTGATCGAACCCACGCTGCGTCCGTACTACAGCC
TGGATGAGCTGCTGGCCCAATGCGACGCATCCGCCGAACTCTCCACCGAAGATCGGGAATGGCTCGACGCCAAGCCTGTT
GGCAGCGAGCTGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0ZYM8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A093DMQ4 |