Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | paaR-paaA-parE/- |
Location | 2061219..2061700 | Replicon | chromosome |
Accession | NZ_CP045213 | ||
Organism | Escherichia coli strain EH41 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | - |
Locus tag | GC231_RS09920 | Protein ID | WP_033812095.1 |
Coordinates | 2061219..2061509 (-) | Length | 97 a.a. |
Antitoxin (Protein)
Gene name | paaA | Uniprot ID | - |
Locus tag | GC231_RS09925 | Protein ID | WP_033812094.1 |
Coordinates | 2061509..2061700 (-) | Length | 64 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GC231_RS09885 (2056301) | 2056301..2056570 | - | 270 | WP_000003742.1 | excisionase | - |
GC231_RS09890 (2056632) | 2056632..2059103 | - | 2472 | WP_220401873.1 | exonuclease | - |
GC231_RS09895 (2059199) | 2059199..2059387 | - | 189 | WP_000092782.1 | DUF1482 family protein | - |
GC231_RS09900 (2059384) | 2059384..2059572 | - | 189 | WP_000450222.1 | cell division inhibition protein DicB | - |
GC231_RS09905 (2060131) | 2060131..2060304 | + | 174 | WP_001376375.1 | hypothetical protein | - |
GC231_RS09910 (2060463) | 2060463..2060642 | - | 180 | Protein_1916 | hypothetical protein | - |
GC231_RS09915 (2060798) | 2060798..2060950 | - | 153 | WP_000380319.1 | DUF1391 family protein | - |
GC231_RS09920 (2061219) | 2061219..2061509 | - | 291 | WP_033812095.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GC231_RS09925 (2061509) | 2061509..2061700 | - | 192 | WP_033812094.1 | hypothetical protein | Antitoxin |
GC231_RS09930 (2061718) | 2061718..2062218 | - | 501 | WP_033812093.1 | helix-turn-helix transcriptional regulator | - |
GC231_RS09935 (2062326) | 2062326..2062601 | + | 276 | WP_047083516.1 | helix-turn-helix transcriptional regulator | - |
GC231_RS09940 (2062585) | 2062585..2063010 | + | 426 | WP_000693925.1 | toxin YdaT family protein | - |
GC231_RS09945 (2063079) | 2063079..2064110 | + | 1032 | WP_228400300.1 | DnaT-like ssDNA-binding domain-containing protein | - |
GC231_RS09950 (2064103) | 2064103..2064564 | + | 462 | WP_000139447.1 | replication protein P | - |
GC231_RS09955 (2064598) | 2064598..2065314 | + | 717 | WP_228400301.1 | DUF1627 domain-containing protein | - |
GC231_RS09960 (2065347) | 2065347..2065628 | + | 282 | WP_220401892.1 | DNA-binding protein | - |
GC231_RS09965 (2065625) | 2065625..2065930 | + | 306 | WP_072095369.1 | DUF4406 domain-containing protein | - |
GC231_RS09970 (2066078) | 2066078..2066260 | + | 183 | WP_001224668.1 | hypothetical protein | - |
GC231_RS09975 (2066253) | 2066253..2066429 | + | 177 | WP_000753060.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | stx2A / stx2B | 2055214..2100593 | 45379 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11192.05 Da Isoelectric Point: 9.9854
>T141491 WP_033812095.1 NZ_CP045213:c2061509-2061219 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC
Download Length: 291 bp
>T141491 NZ_CP059963:c4580281-4579799 [Pectobacterium brasiliense]
ATGGGAATAACTGCGCCAGAGCCATTATCTTCCAGCCATAATCTTGCTGAATTTTGCAGCCAAGAACCGAGCTTGAATGA
ATGGCTAAAAAAGAAAGCGCTAAAAAATCATAGTGCAGGGATTTCTCGTGTATATGTGATTTGCGCTGAAGGCACACATC
AGGTGATTGGATATTATTGTTTATCAACAGGTAGCGTTCAGAGAAATACAGCGCCTGGTGCATATAGACGTAATGCCCCC
GAATCACTACCAGTCATTGTCCTTGGGCGGCTTGCCATTGATCAGGCGTATTCTGGTAAAGGTTTAGGTGTGGCTTTATT
AAAAGACGCGATATTTCGGACTGAGAATATTGCTTTGCAAGTGGGTGTGAGGGCATTAGTCGTTCACGCGCTGGATGAGA
ACGTGCGCAATTTCTACCTTAAATTCGCTTTTGATCCCTCGCCAGTGCAGCCCCTGATGCTACTCTATCCAATTAAAATT
TAG
ATGGGAATAACTGCGCCAGAGCCATTATCTTCCAGCCATAATCTTGCTGAATTTTGCAGCCAAGAACCGAGCTTGAATGA
ATGGCTAAAAAAGAAAGCGCTAAAAAATCATAGTGCAGGGATTTCTCGTGTATATGTGATTTGCGCTGAAGGCACACATC
AGGTGATTGGATATTATTGTTTATCAACAGGTAGCGTTCAGAGAAATACAGCGCCTGGTGCATATAGACGTAATGCCCCC
GAATCACTACCAGTCATTGTCCTTGGGCGGCTTGCCATTGATCAGGCGTATTCTGGTAAAGGTTTAGGTGTGGCTTTATT
AAAAGACGCGATATTTCGGACTGAGAATATTGCTTTGCAAGTGGGTGTGAGGGCATTAGTCGTTCACGCGCTGGATGAGA
ACGTGCGCAATTTCTACCTTAAATTCGCTTTTGATCCCTCGCCAGTGCAGCCCCTGATGCTACTCTATCCAATTAAAATT
TAG
Antitoxin
Download Length: 64 a.a. Molecular weight: 6993.76 Da Isoelectric Point: 4.0270
>AT141491 WP_033812094.1 NZ_CP045213:c2061700-2061509 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE
Download Length: 192 bp
>AT141491 NZ_CP059963:c4580550-4580272 [Pectobacterium brasiliense]
ATGAAACCTGAAACTAAAGAAGCGCCAATCAATATTCGGGCCAAAGCCTCCCAACGGGATTTGATCGATATGGCTGCAAA
CCTTGTGTCAAAATCGCGTACCGATTTTATGCTTGAAGCAGCCTGCCGCGAGGCGCAGGACATTTTGTTGGATCAACGTT
TGTTTATTTTGGATAACGAACAGTTTGACGAATTTTTGGCCGAGTTGGATGCGCCTATCACCGAAGAGCGTCAGGCTCGC
ATTAACGATCTAATGAGCCGCAAATCGCCATGGGAATAA
ATGAAACCTGAAACTAAAGAAGCGCCAATCAATATTCGGGCCAAAGCCTCCCAACGGGATTTGATCGATATGGCTGCAAA
CCTTGTGTCAAAATCGCGTACCGATTTTATGCTTGAAGCAGCCTGCCGCGAGGCGCAGGACATTTTGTTGGATCAACGTT
TGTTTATTTTGGATAACGAACAGTTTGACGAATTTTTGGCCGAGTTGGATGCGCCTATCACCGAAGAGCGTCAGGCTCGC
ATTAACGATCTAATGAGCCGCAAATCGCCATGGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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