Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2061219..2061700 Replicon chromosome
Accession NZ_CP045213
Organism Escherichia coli strain EH41

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag GC231_RS09920 Protein ID WP_033812095.1
Coordinates 2061219..2061509 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag GC231_RS09925 Protein ID WP_033812094.1
Coordinates 2061509..2061700 (-) Length 64 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC231_RS09885 (2056301) 2056301..2056570 - 270 WP_000003742.1 excisionase -
GC231_RS09890 (2056632) 2056632..2059103 - 2472 WP_220401873.1 exonuclease -
GC231_RS09895 (2059199) 2059199..2059387 - 189 WP_000092782.1 DUF1482 family protein -
GC231_RS09900 (2059384) 2059384..2059572 - 189 WP_000450222.1 cell division inhibition protein DicB -
GC231_RS09905 (2060131) 2060131..2060304 + 174 WP_001376375.1 hypothetical protein -
GC231_RS09910 (2060463) 2060463..2060642 - 180 Protein_1916 hypothetical protein -
GC231_RS09915 (2060798) 2060798..2060950 - 153 WP_000380319.1 DUF1391 family protein -
GC231_RS09920 (2061219) 2061219..2061509 - 291 WP_033812095.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GC231_RS09925 (2061509) 2061509..2061700 - 192 WP_033812094.1 hypothetical protein Antitoxin
GC231_RS09930 (2061718) 2061718..2062218 - 501 WP_033812093.1 helix-turn-helix transcriptional regulator -
GC231_RS09935 (2062326) 2062326..2062601 + 276 WP_047083516.1 helix-turn-helix transcriptional regulator -
GC231_RS09940 (2062585) 2062585..2063010 + 426 WP_000693925.1 toxin YdaT family protein -
GC231_RS09945 (2063079) 2063079..2064110 + 1032 WP_228400300.1 DnaT-like ssDNA-binding domain-containing protein -
GC231_RS09950 (2064103) 2064103..2064564 + 462 WP_000139447.1 replication protein P -
GC231_RS09955 (2064598) 2064598..2065314 + 717 WP_228400301.1 DUF1627 domain-containing protein -
GC231_RS09960 (2065347) 2065347..2065628 + 282 WP_220401892.1 DNA-binding protein -
GC231_RS09965 (2065625) 2065625..2065930 + 306 WP_072095369.1 DUF4406 domain-containing protein -
GC231_RS09970 (2066078) 2066078..2066260 + 183 WP_001224668.1 hypothetical protein -
GC231_RS09975 (2066253) 2066253..2066429 + 177 WP_000753060.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2A / stx2B 2055214..2100593 45379


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-91)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 97 a.a.        Molecular weight: 11192.05 Da        Isoelectric Point: 9.9854

>T141491 WP_033812095.1 NZ_CP045213:c2061509-2061219 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T141491 NZ_CP059963:c4580281-4579799 [Pectobacterium brasiliense]
ATGGGAATAACTGCGCCAGAGCCATTATCTTCCAGCCATAATCTTGCTGAATTTTGCAGCCAAGAACCGAGCTTGAATGA
ATGGCTAAAAAAGAAAGCGCTAAAAAATCATAGTGCAGGGATTTCTCGTGTATATGTGATTTGCGCTGAAGGCACACATC
AGGTGATTGGATATTATTGTTTATCAACAGGTAGCGTTCAGAGAAATACAGCGCCTGGTGCATATAGACGTAATGCCCCC
GAATCACTACCAGTCATTGTCCTTGGGCGGCTTGCCATTGATCAGGCGTATTCTGGTAAAGGTTTAGGTGTGGCTTTATT
AAAAGACGCGATATTTCGGACTGAGAATATTGCTTTGCAAGTGGGTGTGAGGGCATTAGTCGTTCACGCGCTGGATGAGA
ACGTGCGCAATTTCTACCTTAAATTCGCTTTTGATCCCTCGCCAGTGCAGCCCCTGATGCTACTCTATCCAATTAAAATT
TAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6993.76 Da        Isoelectric Point: 4.0270

>AT141491 WP_033812094.1 NZ_CP045213:c2061700-2061509 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE

Download         Length: 192 bp

>AT141491 NZ_CP059963:c4580550-4580272 [Pectobacterium brasiliense]
ATGAAACCTGAAACTAAAGAAGCGCCAATCAATATTCGGGCCAAAGCCTCCCAACGGGATTTGATCGATATGGCTGCAAA
CCTTGTGTCAAAATCGCGTACCGATTTTATGCTTGAAGCAGCCTGCCGCGAGGCGCAGGACATTTTGTTGGATCAACGTT
TGTTTATTTTGGATAACGAACAGTTTGACGAATTTTTGGCCGAGTTGGATGCGCCTATCACCGAAGAGCGTCAGGCTCGC
ATTAACGATCTAATGAGCCGCAAATCGCCATGGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References