Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
Location | 4071706..4072504 | Replicon | chromosome |
Accession | NZ_CP045209 | ||
Organism | Escherichia coli strain 4 |
Toxin (Protein)
Gene name | yeeV | Uniprot ID | - |
Locus tag | GC226_RS19785 | Protein ID | WP_000854902.1 |
Coordinates | 4072127..4072504 (+) | Length | 126 a.a. |
Antitoxin (Protein)
Gene name | yeeU | Uniprot ID | A0A093DMQ4 |
Locus tag | GC226_RS19780 | Protein ID | WP_001280952.1 |
Coordinates | 4071706..4072080 (+) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GC226_RS19750 (4068542) | 4068542..4068997 | + | 456 | Protein_3840 | IrmA family protein | - |
GC226_RS19755 (4069076) | 4069076..4069309 | + | 234 | WP_001119729.1 | DUF905 family protein | - |
GC226_RS19760 (4069409) | 4069409..4070227 | + | 819 | WP_001234620.1 | DUF932 domain-containing protein | - |
GC226_RS19765 (4070282) | 4070282..4070767 | + | 486 | WP_001562321.1 | antirestriction protein | - |
GC226_RS19770 (4070783) | 4070783..4071259 | + | 477 | WP_001186726.1 | RadC family protein | - |
GC226_RS19775 (4071322) | 4071322..4071543 | + | 222 | WP_000692311.1 | DUF987 domain-containing protein | - |
GC226_RS19780 (4071706) | 4071706..4072080 | + | 375 | WP_001280952.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
GC226_RS19785 (4072127) | 4072127..4072504 | + | 378 | WP_000854902.1 | TA system toxin CbtA family protein | Toxin |
GC226_RS19790 (4072501) | 4072501..4072989 | + | 489 | WP_000779175.1 | DUF5983 family protein | - |
GC226_RS19795 (4073001) | 4073001..4073198 | + | 198 | WP_000839249.1 | DUF957 domain-containing protein | - |
GC226_RS19800 (4073283) | 4073283..4074125 | + | 843 | WP_001280537.1 | DUF4942 domain-containing protein | - |
GC226_RS19805 (4074468) | 4074468..4075004 | - | 537 | WP_000942795.1 | GspM family type II secretion system protein YghD | - |
GC226_RS19810 (4075006) | 4075006..4076184 | - | 1179 | WP_000094989.1 | type II secretion system protein GspL | - |
GC226_RS19815 (4076181) | 4076181..4077158 | - | 978 | WP_000633239.1 | type II secretion system minor pseudopilin GspK | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Integrative and Conjugative Element | - | gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC | 3997532..4134063 | 136531 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14307.29 Da Isoelectric Point: 7.2922
>T141476 WP_000854902.1 NZ_CP045209:4072127-4072504 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ
Download Length: 378 bp
>T141476 NZ_CP059962:5030315-5030809 [Pectobacterium brasiliense]
ATGATCTCCGCTCCTGAGCCACTCCGCGCCGAACATATACTATCCTCATTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACGAATGCCGCCCCCGGACGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTGGTAGTGCTGGGACGTCTGGCGGTTGATACGTCATTGCATGGTCAAGGTGTTGGACGGGCATTGGTAAGAGATGC
TGGGCTACGGGTGATTCAGGTTGCGGATACTATCGGTATTCGCGGGATGTTAGTTCATGCGCTGTCTGACGAAGCGCGGG
AGTTTTACCTACGAGTGGGGTTTGAGCCTTCGCCGATTGACCCGATGATGTTGATGGTGACGTTAGGGGATTTGGTGGGG
AGTTTATCAATTTGA
ATGATCTCCGCTCCTGAGCCACTCCGCGCCGAACATATACTATCCTCATTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACGAATGCCGCCCCCGGACGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTGGTAGTGCTGGGACGTCTGGCGGTTGATACGTCATTGCATGGTCAAGGTGTTGGACGGGCATTGGTAAGAGATGC
TGGGCTACGGGTGATTCAGGTTGCGGATACTATCGGTATTCGCGGGATGTTAGTTCATGCGCTGTCTGACGAAGCGCGGG
AGTTTTACCTACGAGTGGGGTTTGAGCCTTCGCCGATTGACCCGATGATGTTGATGGTGACGTTAGGGGATTTGGTGGGG
AGTTTATCAATTTGA
Antitoxin
Download Length: 125 a.a. Molecular weight: 13719.50 Da Isoelectric Point: 6.6249
>AT141476 WP_001280952.1 NZ_CP045209:4071706-4072080 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS
Download Length: 375 bp
>AT141476 NZ_CP059962:5030025-5030318 [Pectobacterium brasiliense]
ATGCCAGCGACGAATAGCGTTTCTGTTAAACGTGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGACCTTATCGA
CCGTGCGGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTCGAAGCTGCTCGTGCCGCTGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTGCCCGCCTGGATCAGGCTCCTGCACCAAAT
GCCGCGCTGCGAAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA
ATGCCAGCGACGAATAGCGTTTCTGTTAAACGTGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGACCTTATCGA
CCGTGCGGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTCGAAGCTGCTCGTGCCGCTGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTGCCCGCCTGGATCAGGCTCCTGCACCAAAT
GCCGCGCTGCGAAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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