Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4071706..4072504 Replicon chromosome
Accession NZ_CP045209
Organism Escherichia coli strain 4

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag GC226_RS19785 Protein ID WP_000854902.1
Coordinates 4072127..4072504 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A093DMQ4
Locus tag GC226_RS19780 Protein ID WP_001280952.1
Coordinates 4071706..4072080 (+) Length 125 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC226_RS19750 (4068542) 4068542..4068997 + 456 Protein_3840 IrmA family protein -
GC226_RS19755 (4069076) 4069076..4069309 + 234 WP_001119729.1 DUF905 family protein -
GC226_RS19760 (4069409) 4069409..4070227 + 819 WP_001234620.1 DUF932 domain-containing protein -
GC226_RS19765 (4070282) 4070282..4070767 + 486 WP_001562321.1 antirestriction protein -
GC226_RS19770 (4070783) 4070783..4071259 + 477 WP_001186726.1 RadC family protein -
GC226_RS19775 (4071322) 4071322..4071543 + 222 WP_000692311.1 DUF987 domain-containing protein -
GC226_RS19780 (4071706) 4071706..4072080 + 375 WP_001280952.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GC226_RS19785 (4072127) 4072127..4072504 + 378 WP_000854902.1 TA system toxin CbtA family protein Toxin
GC226_RS19790 (4072501) 4072501..4072989 + 489 WP_000779175.1 DUF5983 family protein -
GC226_RS19795 (4073001) 4073001..4073198 + 198 WP_000839249.1 DUF957 domain-containing protein -
GC226_RS19800 (4073283) 4073283..4074125 + 843 WP_001280537.1 DUF4942 domain-containing protein -
GC226_RS19805 (4074468) 4074468..4075004 - 537 WP_000942795.1 GspM family type II secretion system protein YghD -
GC226_RS19810 (4075006) 4075006..4076184 - 1179 WP_000094989.1 type II secretion system protein GspL -
GC226_RS19815 (4076181) 4076181..4077158 - 978 WP_000633239.1 type II secretion system minor pseudopilin GspK -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - gspM / gspL / gspK / gspJ / gspI / gspH / gspG / gspF / gspE / gspD / gspC 3997532..4134063 136531


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-118)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 14307.29 Da        Isoelectric Point: 7.2922

>T141476 WP_000854902.1 NZ_CP045209:4072127-4072504 [Escherichia coli]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
NACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

>T141476 NZ_CP059962:5030315-5030809 [Pectobacterium brasiliense]
ATGATCTCCGCTCCTGAGCCACTCCGCGCCGAACATATACTATCCTCATTCTGTTGCGGCGTGGAGTCTATGGACAACTG
GCTGAAACAACGGGCGATGAAAAATCAGGTCACTGGCGCATCCCGAACTTTCGTCAGTTGCGATGATTCAAAAGTGTTGG
CGTATTACTCATTGGCTTCCAGCGCCGTGGCAACGAATGCCGCCCCCGGACGCTTTCGTCGCAATATGCCCGATCCGATC
CCGGTGGTAGTGCTGGGACGTCTGGCGGTTGATACGTCATTGCATGGTCAAGGTGTTGGACGGGCATTGGTAAGAGATGC
TGGGCTACGGGTGATTCAGGTTGCGGATACTATCGGTATTCGCGGGATGTTAGTTCATGCGCTGTCTGACGAAGCGCGGG
AGTTTTACCTACGAGTGGGGTTTGAGCCTTCGCCGATTGACCCGATGATGTTGATGGTGACGTTAGGGGATTTGGTGGGG
AGTTTATCAATTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13719.50 Da        Isoelectric Point: 6.6249

>AT141476 WP_001280952.1 NZ_CP045209:4071706-4072080 [Escherichia coli]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRNQHTVTLYAKGLTCEADTLGSCGYVYLAVYPAQAPATTS

Download         Length: 375 bp

>AT141476 NZ_CP059962:5030025-5030318 [Pectobacterium brasiliense]
ATGCCAGCGACGAATAGCGTTTCTGTTAAACGTGAAACATTGAATTTACGCATCAAGCCCGCCGAACGCGACCTTATCGA
CCGTGCGGCGAAGGCCAGAGGAAAAAATCGCACTGATTTTGTCCTCGAAGCTGCTCGTGCCGCTGCAGAGGAAGCGTTGA
TCGATCAGCGCATCATCATGGCAGATCCCGACGCTTATCAGGAATTCCTTGCCCGCCTGGATCAGGCTCCTGCACCAAAT
GCCGCGCTGCGAAAAACCATGCAAACGCCTGCACCGTGGGAACAGAAAAAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A093DMQ4

References