Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 1979737..1980218 Replicon chromosome
Accession NZ_CP045209
Organism Escherichia coli strain 4

Toxin (Protein)


Gene name parE_1 Uniprot ID -
Locus tag GC226_RS09370 Protein ID WP_033812095.1
Coordinates 1979737..1980027 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID -
Locus tag GC226_RS09375 Protein ID WP_033812094.1
Coordinates 1980027..1980218 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GC226_RS09335 (1974891) 1974891..1975160 - 270 WP_000003742.1 excisionase -
GC226_RS09340 (1975222) 1975222..1977624 - 2403 WP_095585566.1 exonuclease -
GC226_RS09345 (1977717) 1977717..1977905 - 189 WP_000092782.1 DUF1482 family protein -
GC226_RS09350 (1977902) 1977902..1978090 - 189 WP_000450222.1 cell division inhibition protein DicB -
GC226_RS09355 (1978649) 1978649..1978822 + 174 WP_001376375.1 hypothetical protein -
GC226_RS09360 (1978981) 1978981..1979160 - 180 Protein_1807 hypothetical protein -
GC226_RS09365 (1979316) 1979316..1979468 - 153 WP_000380319.1 DUF1391 family protein -
GC226_RS09370 (1979737) 1979737..1980027 - 291 WP_033812095.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GC226_RS09375 (1980027) 1980027..1980218 - 192 WP_033812094.1 hypothetical protein Antitoxin
GC226_RS09380 (1980236) 1980236..1980736 - 501 WP_033812093.1 helix-turn-helix transcriptional regulator -
GC226_RS09385 (1980844) 1980844..1981119 + 276 WP_135258987.1 helix-turn-helix transcriptional regulator -
GC226_RS09390 (1981103) 1981103..1981528 + 426 WP_000693925.1 toxin YdaT family protein -
GC226_RS09395 (1981597) 1981597..1982634 + 1038 WP_001373300.1 DnaT-like ssDNA-binding domain-containing protein -
GC226_RS09400 (1982627) 1982627..1983088 + 462 WP_000139447.1 replication protein P -
GC226_RS09405 (1983122) 1983122..1983838 + 717 WP_028985606.1 DUF1627 domain-containing protein -
GC226_RS09410 (1983871) 1983871..1984152 + 282 WP_072094476.1 DNA-binding protein -
GC226_RS09415 (1984149) 1984149..1984454 + 306 WP_072095369.1 DUF4406 domain-containing protein -
GC226_RS09420 (1984602) 1984602..1984784 + 183 WP_001224672.1 hypothetical protein -
GC226_RS09425 (1984777) 1984777..1984953 + 177 WP_000753060.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - stx2A / stx2B 1966635..2093874 127239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11192.05 Da        Isoelectric Point: 9.9854

>T141462 WP_033812095.1 NZ_CP045209:c1980027-1979737 [Escherichia coli]
MLPILWLPSARDDLRQIVAYIAKENPPAARRLKIRIETSVLSLTEHPYLYPPSERVPSLREIVTHPNYIILYRVTTSNIE
IVNVVHSRRQYPNKSC

Download         Length: 291 bp

>T141462 NZ_CP059962:630357-630932 [Pectobacterium brasiliense]
ATGAATCACTCCCCCTATCCTGTGGTACTTGATGCGTGTGTCATTTATCCATCTTTGCTACGGGATTTGCTCATGCATCT
TGGTTTAACAGGGCTATATCAGCCAAAGTGGACGGTACTAATTCAGGAAGAGTGGCAGCGAAATTTGTTGCTAAATAATG
CAGACGTAACGATGGATAAGCTCAGGAACATTGAGCATTTGATGAATAAGGCATTACCTGATGCCAATGTGACTGGGTTC
GAACAACTTATCCCTGCTCTGGTTTTACCTGATGCGGATGATCGACATGTATTGGCCGCTGCGATACGCGCTAATGCAGA
AGTTATCGTCACGGCAAATCTGAAAGATTTTCCAGCCACGTCACTTTCCGAATTTGGAGTGGAAGCCATGCACCCAGACG
AATTCATTGCCGATTTATTTGATCTCAATTCTGCACTGGTGCTTAAAGCCGTTCGAACTTCGCGAACAGCCTTCAGAAAG
CCTCCATTTGATGTGGACGAGTATCTGGATTGTCTCCTGCGTCAGGGGTTACCTATGACGGTAAAAGAACTGGATGCGTA
TCGAGCACTGATTTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 6993.76 Da        Isoelectric Point: 4.0270

>AT141462 WP_033812094.1 NZ_CP045209:c1980218-1980027 [Escherichia coli]
MSTALSPIISEFETVEQENSYNEWLRAKVAASLADPRSGIPHDEVMAEMENLIAQLATTNRSE

Download         Length: 192 bp

>AT141462 NZ_CP059962:629896-630357 [Pectobacterium brasiliense]
ATGAAAAATACTCCTCTAAATAGTTTGAGCCTTCCGGCTCCAAAAGAAATGGAGGCCGCTATCCGTGGACAAAGGCAGCT
TGCAACTTACCTGTCTACGAAGCTGGAAACACAGGAAATTTCGATTCAGGATGCGCACGACATTGCCCATCGGATCGAGT
TGCCTACCTCAGCACTCACGCTTTTGATGAGTATCCTTGGCGAACTGGCGGCGGGTAATGCTGTCCAGATTGTCCCTGTG
CAGGCTGAATTAACGACACAAGAAGCGGCAAATATTCTGAATGTTTCACGGCCACATATGGTGAAGCTTTTGGAAGAAGG
CCATCTTCCTTTCCATAAAACAGGTCGTCATCGCCGCGTGCTTTTTGCTGATTTGATGCAATACAAAGAACAGCGTGAAA
ATGAAAGTATGCAAGCCATGCAGGAGCTGACAGACCGAAGTCAGGAATTCGGGTTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References