Detailed information of TA system TA141416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2613793..2614321
• Replicon: chromosome
• Accession: NZ_CP045198
• Organism: Acinetobacter indicus strain TQ23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GA693_RS12840
• Protein ID: WP_000221359.1
• Coordinates: 2614028..2614321 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA693_RS12835
• Protein ID: WP_160232242.1
• Coordinates: 2613793..2614038 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA693_RS12800	2609794..2610003	+	210	WP_160241748.1	hypothetical protein	-
GA693_RS12805	2610135..2610428	-	294	Protein_2391	IS5/IS1182 family transposase	-
GA693_RS12810	2610525..2611229	+	705	WP_001067784.1	IS6-like element IS1006 family transposase	-
GA693_RS12815	2611351..2611722	+	372	WP_004726814.1	hypothetical protein	-
GA693_RS12820	2612052..2612987	-	936	WP_160241747.1	HNH endonuclease	-
GA693_RS12825	2613382..2613552	+	171	Protein_2395	transposase	-
GA693_RS12830	2613555..2613710	+	156	WP_160241746.1	hypothetical protein	-
GA693_RS12835	2613793..2614038	+	246	WP_160232242.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GA693_RS12840	2614028..2614321	+	294	WP_000221359.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA693_RS12845	2614395..2614805	+	411	WP_160241745.1	PH domain-containing protein	-
GA693_RS12850	2614941..2616073	-	1133	Protein_2400	IS3-like element ISAba14 family transposase	-
GA693_RS12855	2616348..2617388	+	1041	WP_160241744.1	IS481 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	aac(3)-IId / aph(3'')-Ib / aph(6)-Id / tet(X3) / sul2	-	2594300..2637666	43366
	-	inside	IScluster/Tn	aph(3'')-Ib / aph(6)-Id / tet(X3) / sul2	-	2610525..2629704	19179

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11291.58 Da
• Isoelectric Point: 10.6284

>T141416 WP_000221359.1 NZ_CP045198:2614028-2614321 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIKQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T141416 NZ_CP059958:c2612432-2612253 [Pectobacterium brasiliense]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCATCCTAGTAAACCGGGGTTAGTCACAATCCCCCACCCTAAGAAAGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAAGCAGGAATATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9265.64 Da
• Isoelectric Point: 4.3142

>AT141416 WP_160232242.1 NZ_CP045198:2613793-2614038 [Acinetobacter indicus]
MATVNFRVDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT141416 NZ_CP059958:c2612225-2611815 [Pectobacterium brasiliense]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACAGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCTTCAGTAGGCCAATTGGCAAAAAGCGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATCGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAATCACTGATTGACCGAAT
TGATCGTTGCGTGGCGAGTAATCCTGAATTTAAAAGCCGCTCAGGTTTTCTCGCGCAAGCGGCATTAGAGCGAATCTCGT
CTTCCCGATGA