Detailed information of TA system TA141415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2219218..2219746
• Replicon: chromosome
• Accession: NZ_CP045198
• Organism: Acinetobacter indicus strain TQ23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: GA693_RS11005
• Protein ID: WP_000221358.1
• Coordinates: 2219218..2219511 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA693_RS11010
• Protein ID: WP_104988060.1
• Coordinates: 2219501..2219746 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA693_RS10985	2215069..2215944	-	876	WP_160240883.1	pirin family protein	-
GA693_RS10990	2216146..2216709	-	564	WP_005180661.1	alkyl hydroperoxide reductase subunit C	-
GA693_RS10995	2217422..2218512	-	1091	Protein_2038	IS3 family transposase	-
GA693_RS11000	2218760..2219089	+	330	WP_004641881.1	four-helix bundle copper-binding protein	-
GA693_RS11005	2219218..2219511	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA693_RS11010	2219501..2219746	-	246	WP_104988060.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GA693_RS11015	2219926..2220870	-	945	WP_004668309.1	copper resistance protein B	-
GA693_RS11020	2220857..2221195	-	339	WP_104988059.1	hypothetical protein	-
GA693_RS11025	2221182..2223047	-	1866	WP_104988058.1	copper resistance system multicopper oxidase	-
GA693_RS11030	2223932..2224183	-	252	WP_104988057.1	DUF4041 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T141415 WP_000221358.1 NZ_CP045198:c2219511-2219218 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T141415 NZ_CP059958:2588001-2588276 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGATCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCGCGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCCCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT141415 WP_104988060.1 NZ_CP045198:c2219746-2219501 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT141415 NZ_CP059958:2588273-2588635 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTATGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGCTACCCTGAATCATTTGGGGAACGACTGACTATTGCGGCTGCTGAGCGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4