Detailed information of TA system TA141413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 957327..958442
• Replicon: chromosome
• Accession: NZ_CP045198
• Organism: Acinetobacter indicus strain TQ23

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: GA693_RS05080
• Protein ID: WP_016658124.1
• Coordinates: 958278..958442 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: GA693_RS05075
• Protein ID: WP_160241308.1
• Coordinates: 957327..958196 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA693_RS05050	952623..953432	-	810	WP_005178046.1	formate/nitrite transporter family protein	-
GA693_RS05055	953725..954174	+	450	WP_005178047.1	cyanase	-
GA693_RS05060	954363..954647	-	285	WP_160241309.1	KGG domain-containing protein	-
GA693_RS05065	955085..956326	-	1242	WP_016658127.1	MFS transporter	-
GA693_RS05070	956985..957224	+	240	WP_104471337.1	DUF2171 domain-containing protein	-
GA693_RS05075	957327..958196	+	870	WP_160241308.1	SDR family oxidoreductase	Antitoxin
GA693_RS05080	958278..958442	+	165	WP_016658124.1	hypothetical protein	Toxin
GA693_RS05085	958542..959960	-	1419	WP_160241307.1	iron-containing redox enzyme family protein	-
GA693_RS05090	960262..961419	-	1158	WP_171502424.1	fatty acid desaturase	-
GA693_RS05095	961443..962465	-	1023	WP_160241305.1	ferredoxin reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T141413 WP_016658124.1 NZ_CP045198:958278-958442 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T141413 NZ_CP059958:c2454309-2453923 [Pectobacterium brasiliense]
ATGGAGGTTTACAGATTGGCATGGGAAATAGTCACACGGGCACTATTCGATACGTGGTTTGATGAGCAAACTGAAACGGT
ACAGGAAGAGGTTTTGGCACACCTCGCTATACTCGAAGAGGATGGCCCACAGCTAGGGCGACCACAGGTTGATCAGATTA
AAGGCTCAAAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCGGGAGATAAGAAAGGCGAAAATGCAAAGTTGTTCTACGAACGTATGATCAA
GATCGCAGACGCTGAGTTTGCATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31955.08 Da
• Isoelectric Point: 5.1167

>AT141413 WP_160241308.1 NZ_CP045198:957327-958196 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKNHYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNQLIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT141413 NZ_CP059958:c2453936-2453637 [Pectobacterium brasiliense]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCGTTAGCATTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACTGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA

Structures

Toxin

• AlphaFold DB: V2U6R6