Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2114381..2114849 Replicon chromosome
Accession NZ_CP045187
Organism Staphylococcus haemolyticus strain VB19458

Toxin (Protein)


Gene name TsaT Uniprot ID Q4L4Q4
Locus tag D5R78_RS10235 Protein ID WP_011276326.1
Coordinates 2114661..2114849 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID Q4L4Q5
Locus tag D5R78_RS10230 Protein ID WP_011276325.1
Coordinates 2114381..2114638 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R78_RS10195 2109557..2110282 - 726 WP_033079650.1 type I 3-dehydroquinate dehydratase -
D5R78_RS10200 2110445..2110867 + 423 WP_016931015.1 organic hydroperoxide resistance protein -
D5R78_RS10205 2111130..2111621 + 492 WP_049395890.1 GNAT family N-acetyltransferase -
D5R78_RS10210 2111753..2112370 + 618 WP_033079648.1 LysE/ArgO family amino acid transporter -
D5R78_RS10215 2112557..2113165 - 609 WP_011276323.1 phosphoglycerate mutase family protein -
D5R78_RS10220 2113393..2113635 + 243 WP_011276324.1 hypothetical protein -
D5R78_RS10225 2113627..2113830 - 204 WP_033079647.1 sterile alpha motif-like domain-containing protein -
D5R78_RS10230 2114381..2114638 + 258 WP_011276325.1 hypothetical protein Antitoxin
D5R78_RS10235 2114661..2114849 + 189 WP_011276326.1 hypothetical protein Toxin
D5R78_RS10240 2114967..2115548 + 582 WP_033079646.1 orthopoxovirus protein, PF05708 family -
D5R78_RS10245 2115596..2115832 - 237 WP_016931008.1 hypothetical protein -
D5R78_RS10250 2116002..2116748 + 747 WP_033079645.1 membrane lipoprotein lipid attachment site-containing protein -
D5R78_RS10255 2116817..2117425 - 609 WP_033079644.1 GNAT family N-acetyltransferase -
D5R78_RS10260 2117562..2118308 + 747 WP_033079643.1 poly-gamma-glutamate hydrolase family protein -
D5R78_RS10265 2118384..2118671 + 288 WP_033079642.1 hypothetical protein -
D5R78_RS10270 2118915..2119139 + 225 WP_033079641.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage fusB - 2113393..2180397 67004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-113)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7110.80 Da        Isoelectric Point: 9.6269

>T141362 WP_011276326.1 NZ_CP045187:2114661-2114849 [Staphylococcus haemolyticus]
MSLHLTILLWLGIIFVIAASIILGLLLKSKKEERKESYLGFTVIFYIFGFALLIYVFIFGIL

Download         Length: 189 bp

>T141362 NZ_CP059955:1230309-1230695 [Pectobacterium brasiliense]
ATGGAGGTTTACAGATTGGCATGGGAAATAGTCACACGGGCACTATTCGATACGTGGTTTGATGAGCAAACTGAAACGGT
ACAGGAAGAGGTTTTGGCACACCTCGCTATACTCGAAGAGGATGGCCCACAGCTAGGGCGACCACAGGTTGATCAGATTA
AAGGCTCAAAATACAAAAATATGAAGGAGCTTCGAGTTCAGGTTGGCGGCCACCCATTCCGAACATTCTTCGCGTTTGAC
CGGACACGTAAAGCGATTGTTTTATGTGCGGGAGATAAGAAAGGCGAAAATGCAAAGTTGTTCTACGAACGTATGATCAA
GATCGCAGACGCTGAGTTTGCATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9914.97 Da        Isoelectric Point: 4.0625

>AT141362 WP_011276325.1 NZ_CP045187:2114381-2114638 [Staphylococcus haemolyticus]
MNNNKIFWINIFMTLLFLGFNIIVTYNADLDDFFWLIPGLTISGITIVLSLSTALICKNLVSEVIFLINIVMLLYYIYPM
VYTFF

Download         Length: 258 bp

>AT141362 NZ_CP059955:1230682-1230981 [Pectobacterium brasiliense]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGCGCCCGCATTGAAGCGCGCACGGCTGAGATCCG
TCAGGAAATCACTTTAGCGAAACTACGCGAAGAGCTGAACATGTCGCAGACTCAGCTTGCGTTAGCATTGGGCGTCAAGC
AGCCATCTATTGTTAAGATGGAGAAGGTCGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTCACTGCCCTAGGC
GGCAAGCTTACGCTAGATGTGACCTTGCCTGATGGTAAGCGTATCGCGCTTACTTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KAB5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1KAX9

References