Detailed information of TA system TA141361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1119025..1119796
• Replicon: chromosome
• Accession: NZ_CP045187
• Organism: Staphylococcus haemolyticus strain VB19458

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: D5R78_RS13310
• Protein ID: WP_011275410.1
• Coordinates: 1119647..1119796 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: D5R78_RS05500
• Protein ID: WP_011275409.1
• Coordinates: 1119025..1119624 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R78_RS05480	1114908..1116362	+	1455	WP_011275405.1	ABC transporter substrate-binding protein/permease	-
D5R78_RS05485	1116355..1117077	+	723	WP_016931345.1	amino acid ABC transporter ATP-binding protein	-
D5R78_RS05490	1117255..1118382	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
D5R78_RS05495	1118383..1118853	+	471	WP_011275408.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
D5R78_RS05500	1119025..1119624	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
D5R78_RS13310	1119647..1119796	+	150	WP_011275410.1	hypothetical protein	Toxin
D5R78_RS05505	1120007..1120402	+	396	WP_011275411.1	hypothetical protein	-
D5R78_RS05510	1120609..1121994	+	1386	WP_011275412.1	class II fumarate hydratase	-
D5R78_RS05515	1122060..1122884	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
D5R78_RS05520	1123072..1124181	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T141361 WP_011275410.1 NZ_CP045187:1119647-1119796 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T141361 NZ_CP059955:c1110413-1109931 [Pectobacterium brasiliense]
ATGGGAATAACTGCGCCAGAGCCATTATCTTCCAGCCATAATCTTGCTGAATTTTGCAGCCAAGAACCGAGCTTGAATGA
ATGGCTAAAAAAGAAAGCGCTAAAAAATCATAGTGCAGGGATTTCTCGTGTATATGTGATTTGCGCTGAAGGCACACATC
AGGTGATTGGATATTATTGTTTATCAACAGGTAGCGTTCAGAGAAATACAGCGCCTGGTGCATATAGACGTAATGCCCCC
GAATCACTACCAGTCATTGTCCTTGGGCGGCTTGCCATTGATCAGGCGTATTCTGGTAAAGGTTTAGGTGTGGCTTTATT
AAAAGACGCGATATTTCGGACTGAGAATATTGCTTTGCAAGTGGGTGTGAGGGCATTAGTCGTTCACGCGCTGGATGAGA
ACGTGCGCAATTTCTACCTTAAATTCGCTTTTGATCCCTCGCCAGTGCAGCCCCTGATGCTACTCTATCCAATTAAAATT
TAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT141361 WP_011275409.1 NZ_CP045187:1119025-1119624 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT141361 NZ_CP059955:c1110682-1110404 [Pectobacterium brasiliense]
ATGAAACCTGAAACTAAAGAAGCGCCAATCAATATTCGGGCCAAAGCCTCCCAACGGGATTTGATCGATATGGCTGCAAA
CCTTGTGTCAAAATCGCGTACCGATTTTATGCTTGAAGCAGCCTGCCGCGAGGCGCAGGACATTTTGTTGGATCAACGTT
TGTTTATTTTGGATAACGAACAGTTTGACGAATTTTTGGCCGAGTTGGATGCGCCTATCACCGAAGAGCGTCAGGCTCGC
ATTAACGATCTAATGAGCCGCAAATCGCCATGGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2