Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 969319..969851 Replicon chromosome
Accession NZ_CP045187
Organism Staphylococcus haemolyticus strain VB19458

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag D5R78_RS04655 Protein ID WP_011275272.1
Coordinates 969486..969851 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q4L7V4
Locus tag D5R78_RS04650 Protein ID WP_011275271.1
Coordinates 969319..969489 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D5R78_RS04625 965105..965584 + 480 WP_011275266.1 PH domain-containing protein -
D5R78_RS04630 965577..967100 + 1524 WP_016931363.1 PH domain-containing protein -
D5R78_RS04635 967093..967620 + 528 WP_033080076.1 PH domain-containing protein -
D5R78_RS04640 967630..967989 + 360 WP_011275269.1 holo-ACP synthase -
D5R78_RS04645 968085..969233 + 1149 WP_016931365.1 alanine racemase -
D5R78_RS04650 969319..969489 + 171 WP_011275271.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
D5R78_RS04655 969486..969851 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
D5R78_RS04660 970159..971160 + 1002 WP_011275273.1 PP2C family protein-serine/threonine phosphatase -
D5R78_RS04665 971259..971585 + 327 WP_011275274.1 anti-sigma factor antagonist -
D5R78_RS04670 971587..972066 + 480 WP_011275275.1 anti-sigma B factor RsbW -
D5R78_RS04675 972041..972811 + 771 WP_011275276.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 946186..983736 37550


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T141360 WP_011275272.1 NZ_CP045187:969486-969851 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

>T141360 NZ_CP059955:c1096617-1096342 [Pectobacterium brasiliense]
ATGCAGGGAAAAATAGCCAGCCTACGAAAGAAGCAGCGGGAAACGCTGATCCAAATTTTCAAAACACCAGTACTTTCAGG
TGTTAAATGGTCGAATATTGAGTCACTCGTTACTGCGTTAGGCGGTGAAATTAAGGAAGGTAGCGGATCGCGAGTGCGAT
TTTTATTGAACGGGAGTATCGCCCGGTTCCATCGTCCCCATCCGTCACCGGATACTGATAAAGGTGCACTGGTTAGCCTG
CGTGAATGGCTGGAAAGTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT141360 WP_011275271.1 NZ_CP045187:969319-969489 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYLISNYKSE

Download         Length: 171 bp

>AT141360 NZ_CP059955:c1096345-1095983 [Pectobacterium brasiliense]
ATGACGAAAGCACTCAACACACCAAATACGATGGTTGTTTCTGGACAACCGGCCATTATCAGTTATGTACCGGAAATGGG
TATGTTTCGCGGTAAGTTTATTGGTTTATCTGGCTACTGTGATTTTGTCGCCGACAGTATTAATGGCTTGAGAAGCGAGG
GTGAAATTTCGCTACGCGAATATCTGGAAGACTGTCAGGAAAATGGCATTGAACCTTACGAGCGTGAAGAGAAGGTGAAA
ACATTCACCCTCCGCTACCCTGAATCATTTGGGGAACGACTGACTATTGCGGCTGCTGAGCGCCAAATTTCAGTGAATAC
GTTTATTGTTGAAACGCTTAGCGAACACCTGAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2A1K7K7

References