Detailed information of TA system TA141359

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 956406..956917
• Replicon: chromosome
• Accession: NZ_CP045187
• Organism: Staphylococcus haemolyticus strain VB19458

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: D5R78_RS04590
• Protein ID: WP_011275259.1
• Coordinates: 956711..956917 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: D5R78_RS04585
• Protein ID: WP_011275258.1
• Coordinates: 956406..956699 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D5R78_RS04565	951565..952440	+	876	WP_011275255.1	membrane protein insertase YidC	-
D5R78_RS04570	952635..953947	+	1313	Protein_905	ISL3 family transposase	-
D5R78_RS04575	953994..954635	-	642	WP_119881121.1	HD domain-containing protein	-
D5R78_RS04580	954735..956219	-	1485	WP_119881119.1	cardiolipin synthase	-
D5R78_RS04585	956406..956699	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
D5R78_RS04590	956711..956917	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
D5R78_RS04595	957025..957162	+	138	WP_011275260.1	hypothetical protein	-
D5R78_RS04600	957459..959124	+	1666	Protein_911	IS1182 family transposase	-
D5R78_RS04605	959099..960298	-	1200	WP_119881069.1	rod shape-determining protein RodA	-
D5R78_RS04610	960716..961786	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	946186..983736	37550
	-	inside	IScluster/Tn	-	-	952635..959141	6506

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T141359 WP_011275259.1 NZ_CP045187:956711-956917 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T141359 NZ_CP059955:1072186-1072365 [Pectobacterium brasiliense]
ATGGATAGCAGGACGTTAATAGCAGAAATCAAGGCCGATGGGTGGGAACTGATAAGAGTGAACGGAAGCCACCACCATTT
TATGCATCCTAGTAAACCGGGGTTAGTCACAATCCCCCACCCTAAGAAAGATTTACCGATAGGCACGGTAAAAAGCATCA
GGAAACAAGCAGGAATATGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT141359 WP_011275258.1 NZ_CP045187:956406-956699 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT141359 NZ_CP059955:1072393-1072803 [Pectobacterium brasiliense]
ATGTTTTATCCGATTGCAATTGAAGCAGGCGACGATACCCACGCATACGGTGTAACAGTGCCAGATCTACCGGGCTGTTT
TTCTGCAGGCGATACGCTAGACGATGCCATCGCGAATGCTAAAGAGGCGATTACCGGACATATCGAACTGCTGATCGAGA
TGGGTCAGGATATTCCCACCGTGTCTTCAGTAGGCCAATTGGCAAAAAGCGCAGAATACGCTGGGTACACGTGGGCGGTT
GTTGATATCGATGTGACGCGTTTAATGGGCGGTTCAGAAAAAATTAACGTCACGCTGCCTAAATCACTGATTGACCGAAT
TGATCGTTGCGTGGCGAGTAATCCTGAATTTAAAAGCCGCTCAGGTTTTCTCGCGCAAGCGGCATTAGAGCGAATCTCGT
CTTCCCGATGA

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8