Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2281236..2282202 Replicon chromosome
Accession NZ_CP045163
Organism Yersinia pestis strain SCPM-O-B-6291 (C-25)

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag GCK68_RS10520 Protein ID WP_002210981.1
Coordinates 2281744..2282202 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag GCK68_RS10515 Protein ID WP_002210982.1
Coordinates 2281236..2281682 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK68_RS10495 2276825..2277799 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
GCK68_RS10500 2277962..2278465 + 504 WP_002210984.1 thiol peroxidase -
GCK68_RS10505 2278718..2279176 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
GCK68_RS10510 2279323..2280900 - 1578 WP_002210983.1 transcriptional regulator TyrR -
GCK68_RS10515 2281236..2281682 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
GCK68_RS10520 2281744..2282202 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
GCK68_RS10525 2282212..2283273 - 1062 WP_002210980.1 YcjF family protein -
GCK68_RS10530 2283270..2284667 - 1398 WP_002210979.1 YcjX family protein -
GCK68_RS10535 2284648..2284890 - 243 WP_002216375.1 phage shock protein PspD -
GCK68_RS10540 2284975..2285334 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
GCK68_RS10545 2285334..2285561 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
GCK68_RS10550 2285723..2286388 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2278718..2279176 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T141355 WP_002210981.1 NZ_CP045163:2281744-2282202 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T141355 NZ_CP059948:c115828-115523 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT141355 WP_002210982.1 NZ_CP045163:2281236-2281682 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT141355 NZ_CP059948:c116048-115830 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References