Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3481956..3482628 Replicon chromosome
Accession NZ_CP045158
Organism Yersinia pestis subsp. pestis bv. Medievalis strain SCPM-O-B-6530

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag DJY80_RS16590 Protein ID WP_002215144.1
Coordinates 3481956..3482381 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag DJY80_RS16595 Protein ID WP_002209939.1
Coordinates 3482362..3482628 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJY80_RS16570 3477629..3478147 + 519 WP_002209934.1 flavodoxin FldB -
DJY80_RS16575 3478237..3479694 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
DJY80_RS16580 3479815..3481233 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
DJY80_RS16585 3481258..3481956 - 699 WP_002209937.1 two-component system response regulator CreB -
DJY80_RS16590 3481956..3482381 - 426 WP_002215144.1 protein YgfX Toxin
DJY80_RS16595 3482362..3482628 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
DJY80_RS16600 3482945..3483937 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
DJY80_RS16605 3484010..3484507 - 498 WP_002209941.1 DUF2165 family protein -
DJY80_RS16610 3484765..3485466 - 702 WP_002209942.1 hemolysin III family protein -
DJY80_RS16615 3485668..3486771 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T141342 WP_002215144.1 NZ_CP045158:c3482381-3481956 [Yersinia pestis subsp. pestis bv. Medievalis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T141342 NZ_CP059947:2653078-2653185 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT141342 WP_002209939.1 NZ_CP045158:c3482628-3482362 [Yersinia pestis subsp. pestis bv. Medievalis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT141342 NZ_CP059947:c2653028-2652965 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References