Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2075105..2076071 Replicon chromosome
Accession NZ_CP045158
Organism Yersinia pestis subsp. pestis bv. Medievalis strain SCPM-O-B-6530

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag DJY80_RS09865 Protein ID WP_002210981.1
Coordinates 2075105..2075563 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag DJY80_RS09870 Protein ID WP_002210982.1
Coordinates 2075625..2076071 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJY80_RS09835 2070919..2071584 + 666 WP_002210975.1 phage shock protein PspA -
DJY80_RS09840 2071746..2071973 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
DJY80_RS09845 2071973..2072332 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
DJY80_RS09850 2072417..2072659 + 243 WP_002216375.1 phage shock protein PspD -
DJY80_RS09855 2072640..2074037 + 1398 WP_002210979.1 YcjX family protein -
DJY80_RS09860 2074034..2075095 + 1062 WP_002210980.1 YcjF family protein -
DJY80_RS09865 2075105..2075563 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
DJY80_RS09870 2075625..2076071 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
DJY80_RS09875 2076407..2077984 + 1578 WP_002210983.1 transcriptional regulator TyrR -
DJY80_RS09880 2078131..2078256 - 126 Protein_1822 IS200/IS605 family transposase -
DJY80_RS09885 2078343..2079365 + 1023 WP_000255944.1 IS21-like element IS100 family transposase -
DJY80_RS09890 2079362..2080144 + 783 WP_001317493.1 IS21-like element IS100kyp family helper ATPase IstB -
DJY80_RS09895 2080195..2080548 - 354 WP_152329115.1 IS200/IS605 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T141331 WP_002210981.1 NZ_CP045158:c2075563-2075105 [Yersinia pestis subsp. pestis bv. Medievalis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T141331 NZ_CP059947:881898-882305 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT141331 WP_002210982.1 NZ_CP045158:c2076071-2075625 [Yersinia pestis subsp. pestis bv. Medievalis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT141331 NZ_CP059947:881651-881917 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References