Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1064554..1065174 Replicon chromosome
Accession NZ_CP045158
Organism Yersinia pestis subsp. pestis bv. Medievalis strain SCPM-O-B-6530

Toxin (Protein)


Gene name Hha Uniprot ID Q66DR5
Locus tag DJY80_RS05060 Protein ID WP_002208622.1
Coordinates 1064554..1064757 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q66DR4
Locus tag DJY80_RS05065 Protein ID WP_002218472.1
Coordinates 1064806..1065174 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DJY80_RS05030 1059576..1059914 + 339 WP_002208627.1 P-II family nitrogen regulator -
DJY80_RS05035 1059954..1061243 + 1290 WP_002228344.1 ammonium transporter AmtB -
DJY80_RS05040 1061503..1062363 - 861 WP_002208625.1 acyl-CoA thioesterase II -
DJY80_RS05045 1062620..1063141 + 522 WP_002208624.1 lipoprotein -
DJY80_RS05050 1063277..1063666 - 390 WP_002208623.1 MGMT family protein -
DJY80_RS05060 1064554..1064757 - 204 WP_002208622.1 expression modulating protein YmoA Toxin
DJY80_RS05065 1064806..1065174 - 369 WP_002218472.1 Hha toxicity modulator TomB Antitoxin
DJY80_RS05070 1065333..1065686 - 354 WP_002208619.1 hypothetical protein -
DJY80_RS05075 1066560..1066703 - 144 WP_002208618.1 type B 50S ribosomal protein L36 -
DJY80_RS05080 1066719..1066979 - 261 WP_002208617.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8063.31 Da        Isoelectric Point: 6.4573

>T141330 WP_002208622.1 NZ_CP045158:c1064757-1064554 [Yersinia pestis subsp. pestis bv. Medievalis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK

Download         Length: 204 bp

>T141330 NZ_CP059947:c608765-608301 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14215.00 Da        Isoelectric Point: 4.6121

>AT141330 WP_002218472.1 NZ_CP045158:c1065174-1064806 [Yersinia pestis subsp. pestis bv. Medievalis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT

Download         Length: 369 bp

>AT141330 NZ_CP059947:c609100-608765 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2K5S

Antitoxin

Source ID Structure
AlphaFold DB Q66DR4

References