Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3788823..3789495 Replicon chromosome
Accession NZ_CP045154
Organism Yersinia pestis strain SCPM-O-B-5935 (I-1996)

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag GCK71_RS17980 Protein ID WP_002215144.1
Coordinates 3788823..3789248 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag GCK71_RS17985 Protein ID WP_002209939.1
Coordinates 3789229..3789495 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK71_RS17960 3784496..3785014 + 519 WP_002209934.1 flavodoxin FldB -
GCK71_RS17965 3785104..3786561 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
GCK71_RS17970 3786682..3788100 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
GCK71_RS17975 3788125..3788823 - 699 WP_002209937.1 two-component system response regulator CreB -
GCK71_RS17980 3788823..3789248 - 426 WP_002215144.1 protein YgfX Toxin
GCK71_RS17985 3789229..3789495 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
GCK71_RS17990 3789812..3790804 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
GCK71_RS17995 3790877..3791374 - 498 WP_002209941.1 DUF2165 family protein -
GCK71_RS18000 3791632..3792333 - 702 WP_002209942.1 hemolysin III family protein -
GCK71_RS18005 3792535..3793638 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T141327 WP_002215144.1 NZ_CP045154:c3789248-3788823 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T141327 NZ_CP059929:4507136-4507312 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT141327 WP_002209939.1 NZ_CP045154:c3789495-3789229 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT141327 NZ_CP059929:4507358-4507774 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References