Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2800506..2801472 Replicon chromosome
Accession NZ_CP045154
Organism Yersinia pestis strain SCPM-O-B-5935 (I-1996)

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag GCK71_RS13295 Protein ID WP_002210981.1
Coordinates 2801014..2801472 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag GCK71_RS13290 Protein ID WP_002210982.1
Coordinates 2800506..2800952 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK71_RS13270 2796095..2797069 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
GCK71_RS13275 2797232..2797735 + 504 WP_002210984.1 thiol peroxidase -
GCK71_RS13280 2797988..2798446 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
GCK71_RS13285 2798593..2800170 - 1578 WP_002210983.1 transcriptional regulator TyrR -
GCK71_RS13290 2800506..2800952 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
GCK71_RS13295 2801014..2801472 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
GCK71_RS13300 2801482..2802543 - 1062 WP_002210980.1 YcjF family protein -
GCK71_RS13305 2802540..2803937 - 1398 WP_002210979.1 YcjX family protein -
GCK71_RS13310 2803918..2804160 - 243 WP_002216375.1 phage shock protein PspD -
GCK71_RS13315 2804245..2804604 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
GCK71_RS13320 2804604..2804831 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
GCK71_RS13325 2804993..2805658 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2797988..2798446 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T141325 WP_002210981.1 NZ_CP045154:2801014-2801472 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T141325 NZ_CP059929:c4257092-4256718 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT141325 WP_002210982.1 NZ_CP045154:2800506-2800952 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT141325 NZ_CP059929:c4257549-4257181 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References