Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2236141..2236787 Replicon chromosome
Accession NZ_CP045154
Organism Yersinia pestis strain SCPM-O-B-5935 (I-1996)

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag GCK71_RS10590 Protein ID WP_002214976.1
Coordinates 2236605..2236787 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag GCK71_RS10585 Protein ID WP_002211129.1
Coordinates 2236141..2236560 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK71_RS10565 2231212..2232207 + 996 WP_002211125.1 substrate-binding domain-containing protein -
GCK71_RS10570 2232273..2233850 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
GCK71_RS10575 2233853..2234875 + 1023 WP_002214974.1 ABC transporter permease -
GCK71_RS10580 2234924..2235883 + 960 WP_002223882.1 sugar kinase -
GCK71_RS10585 2236141..2236560 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GCK71_RS10590 2236605..2236787 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
GCK71_RS10595 2236994..2237776 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
GCK71_RS10600 2237779..2238048 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
GCK71_RS10605 2238154..2238894 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
GCK71_RS10610 2238975..2239511 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
GCK71_RS10615 2239511..2239927 - 417 WP_002211134.1 flagellar motor switch protein FliN -
GCK71_RS10620 2239924..2240925 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
GCK71_RS10625 2240931..2241401 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T141324 WP_002214976.1 NZ_CP045154:c2236787-2236605 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T141324 NZ_CP059929:4245194-4245448 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAATCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT141324 WP_002211129.1 NZ_CP045154:c2236560-2236141 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT141324 NZ_CP059929:4244946-4245197 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References