Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3275603..3276275 Replicon chromosome
Accession NZ_CP045149
Organism Yersinia pestis strain SCPM-O-DNA-18 (I-3113)

Toxin (Protein)


Gene name cptA Uniprot ID Q666S4
Locus tag GCK70_RS15615 Protein ID WP_002215144.1
Coordinates 3275603..3276028 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID Q666S3
Locus tag GCK70_RS15620 Protein ID WP_002209939.1
Coordinates 3276009..3276275 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK70_RS15595 3271276..3271794 + 519 WP_002209934.1 flavodoxin FldB -
GCK70_RS15600 3271884..3273341 - 1458 WP_002220113.1 cell envelope integrity protein CreD -
GCK70_RS15605 3273462..3274880 - 1419 WP_002209936.1 two-component system sensor histidine kinase CreC -
GCK70_RS15610 3274905..3275603 - 699 WP_002209937.1 two-component system response regulator CreB -
GCK70_RS15615 3275603..3276028 - 426 WP_002215144.1 protein YgfX Toxin
GCK70_RS15620 3276009..3276275 - 267 WP_002209939.1 FAD assembly factor SdhE Antitoxin
GCK70_RS15625 3276592..3277584 + 993 WP_002209940.1 tRNA-modifying protein YgfZ -
GCK70_RS15630 3277657..3278154 - 498 WP_002209941.1 DUF2165 family protein -
GCK70_RS15635 3278412..3279113 - 702 WP_002209942.1 hemolysin III family protein -
GCK70_RS15640 3279315..3280418 - 1104 WP_002209943.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 16510.43 Da        Isoelectric Point: 10.3799

>T141312 WP_002215144.1 NZ_CP045149:c3276028-3275603 [Yersinia pestis]
VAQWRCNLRVSWHTQLFSLLAHGILVILTLVAPWPLGYTALWLVLLTLVVFECIRSQKRIKSCQGEIRLKPGNLVRWKRH
EWTVVKPPWITRYGVLLHLQQTGGHATRKRLWLSADSMSEDEWRQLCLLLRHSFESDDGTM

Download         Length: 426 bp

>T141312 NZ_CP059929:459791-459898 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10511.98 Da        Isoelectric Point: 4.6533

>AT141312 WP_002209939.1 NZ_CP045149:c3276275-3276009 [Yersinia pestis]
MEIDNKARIHWACRRGMRELDISIMPFFEYEYDSLSDNEKQAFIRLLECDDPDLFNWLMNHGEPQDSELYQMVKLIQSRN
KARGPVAM

Download         Length: 267 bp

>AT141312 NZ_CP059929:c459744-459678 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q666S4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XP12

References