Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2732780..2733426 Replicon chromosome
Accession NZ_CP045145
Organism Yersinia pestis strain SCPM-O-B-6899 (231)

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag GCK69_RS12805 Protein ID WP_002214976.1
Coordinates 2732780..2732962 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag GCK69_RS12810 Protein ID WP_002211129.1
Coordinates 2733007..2733426 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GCK69_RS12770 2728166..2728636 + 471 WP_002227961.1 flagellar basal body-associated protein FliL -
GCK69_RS12775 2728642..2729643 + 1002 WP_002211135.1 flagellar motor switch protein FliM -
GCK69_RS12780 2729640..2730056 + 417 WP_002211134.1 flagellar motor switch protein FliN -
GCK69_RS12785 2730056..2730592 + 537 WP_002211133.1 flagellar biosynthetic protein FliO -
GCK69_RS12790 2730673..2731413 + 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
GCK69_RS12795 2731519..2731788 + 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
GCK69_RS12800 2731791..2732573 + 783 WP_002211130.1 flagellar type III secretion system protein FliR -
GCK69_RS12805 2732780..2732962 + 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
GCK69_RS12810 2733007..2733426 + 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GCK69_RS12815 2733684..2734643 - 960 WP_002211128.1 sugar kinase -
GCK69_RS12820 2734692..2735714 - 1023 WP_002214974.1 ABC transporter permease -
GCK69_RS12825 2735717..2737294 - 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
GCK69_RS12830 2737360..2738355 - 996 WP_002211125.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T141287 WP_002214976.1 NZ_CP045145:2732780-2732962 [Yersinia pestis]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T141287 NZ_CP059917:2287858-2288034 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTGGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCAAGGGCGACGCAGTGTCATGCCGCGTCACCCCAGTGATGAGATAAAAGAACCATTGCGTAAAGCAATCCTGAAGC
AACTCGGTTTAAATTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT141287 WP_002211129.1 NZ_CP045145:2733007-2733426 [Yersinia pestis]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT141287 NZ_CP059917:2288078-2288494 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACTCCTGCGCCGGAAGGCGGTTATGTGGTTTCTTTTGTAGATATCCCTGAAGCGTTGAC
GCAGGGAGAAACTGTTGCTGAAGCGATGGAAGCAGCAAAAGATGCCTTACTCACCGCATTTGATTTTTATTTTGAAGATA
ATGAGCTAATCCCGTTGCCTTCGCCATTAACTAACAACGATCACTTTATTGAAGTGCCTTTAAGTATCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGACGAATTGGCAAACCTAAACAGGAGAT
TACTCGCTTATTTAACTTGCACCATGCTACAAAAATCGACGCCGTCCAGCTTGCGGCTAAGGCGCTTGGCAAAGAGTTAT
CACTGGTGATGGTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References