Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1154821..1155441 | Replicon | chromosome |
Accession | NZ_CP045145 | ||
Organism | Yersinia pestis strain SCPM-O-B-6899 (231) |
Toxin (Protein)
Gene name | Hha | Uniprot ID | Q66DR5 |
Locus tag | GCK69_RS05340 | Protein ID | WP_002208622.1 |
Coordinates | 1154821..1155024 (-) | Length | 68 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | Q66DR4 |
Locus tag | GCK69_RS05345 | Protein ID | WP_002218472.1 |
Coordinates | 1155073..1155441 (-) | Length | 123 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GCK69_RS05310 | 1149843..1150181 | + | 339 | WP_002208627.1 | P-II family nitrogen regulator | - |
GCK69_RS05315 | 1150221..1151510 | + | 1290 | WP_002228344.1 | ammonium transporter AmtB | - |
GCK69_RS05320 | 1151770..1152630 | - | 861 | WP_002208625.1 | acyl-CoA thioesterase II | - |
GCK69_RS05325 | 1152887..1153408 | + | 522 | WP_002208624.1 | lipoprotein | - |
GCK69_RS05330 | 1153544..1153933 | - | 390 | WP_002208623.1 | MGMT family protein | - |
GCK69_RS05340 | 1154821..1155024 | - | 204 | WP_002208622.1 | expression modulating protein YmoA | Toxin |
GCK69_RS05345 | 1155073..1155441 | - | 369 | WP_002218472.1 | Hha toxicity modulator TomB | Antitoxin |
GCK69_RS05350 | 1155600..1155953 | - | 354 | WP_002208619.1 | hypothetical protein | - |
GCK69_RS05355 | 1156827..1156970 | - | 144 | WP_002208618.1 | type B 50S ribosomal protein L36 | - |
GCK69_RS05360 | 1156986..1157246 | - | 261 | WP_002208617.1 | type B 50S ribosomal protein L31 | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 68 a.a. Molecular weight: 8063.31 Da Isoelectric Point: 6.4573
>T141285 WP_002208622.1 NZ_CP045145:c1155024-1154821 [Yersinia pestis]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPTVWQHVK
Download Length: 204 bp
>T141285 NZ_CP059917:c2043258-2043151 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 14215.00 Da Isoelectric Point: 4.6121
>AT141285 WP_002218472.1 NZ_CP045145:c1155441-1155073 [Yersinia pestis]
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT
MDEYSPKRHDIAQLKFLCESLYDEGIATLGDSHHGWINDPTSAINLQLNDLIEHIASFVMSFKIKYPDGSQLSELVEEYL
DDTYTLFSSYGINDPELRRWQKTKEHLFRLFSGEYVCTLMKT
Download Length: 369 bp
>AT141285 NZ_CP059917:2043311-2043372 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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