Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3610002..3610675 Replicon chromosome
Accession NZ_CP045144
Organism Ancylobacter sp. TS-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GBB76_RS16965 Protein ID WP_152304391.1
Coordinates 3610002..3610424 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GBB76_RS16970 Protein ID WP_149577072.1
Coordinates 3610421..3610675 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBB76_RS16940 3606231..3606968 + 738 WP_152304387.1 aspartate/glutamate racemase family protein -
GBB76_RS16945 3606969..3607655 + 687 WP_152304388.1 GntR family transcriptional regulator -
GBB76_RS16950 3607758..3607976 + 219 WP_152304389.1 helix-turn-helix domain-containing protein -
GBB76_RS16955 3608031..3608357 - 327 WP_152304390.1 DUF736 domain-containing protein -
GBB76_RS16960 3609009..3609429 - 421 Protein_3352 hypothetical protein -
GBB76_RS18795 3609552..3609719 - 168 WP_188079217.1 hypothetical protein -
GBB76_RS16965 3610002..3610424 - 423 WP_152304391.1 type II toxin-antitoxin system VapC family toxin Toxin
GBB76_RS16970 3610421..3610675 - 255 WP_149577072.1 plasmid stabilization protein Antitoxin
GBB76_RS16975 3610760..3611686 - 927 WP_152304392.1 DUF2493 domain-containing protein -
GBB76_RS16980 3612056..3613090 - 1035 WP_152304393.1 toprim domain-containing protein -
GBB76_RS16985 3613160..3615223 - 2064 WP_152304394.1 ParB/Srx family N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3584622..3706943 122321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14879.95 Da        Isoelectric Point: 4.5296

>T141284 WP_152304391.1 NZ_CP045144:c3610424-3610002 [Ancylobacter sp. TS-1]
MILLDTNVISEAMKPTPDDTVRAWLDEQAAETLYLSSVTIAELLYGIGALPAGKRKDRLTEALDGVMELFADRVLPFDIA
AARRYADLAVKARAAGKGFPTPDGYIAAIAAAHGFTVASRDTSAFNAAGVAVINPWNVDN

Download         Length: 423 bp

>T141284 NZ_CP059917:c1927575-1927081 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9379.62 Da        Isoelectric Point: 9.1399

>AT141284 WP_149577072.1 NZ_CP045144:c3610675-3610421 [Ancylobacter sp. TS-1]
MPAVTIRNLSEATHRALKVRAAQHGRSTEAEMREILETAVRPDTRLRLGTALAERSRRLGLTNEDIDALSPARDRTPAEP
MSFE

Download         Length: 255 bp

>AT141284 NZ_CP059917:c1927865-1927572 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References