Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1801291..1801832 Replicon chromosome
Accession NZ_CP045144
Organism Ancylobacter sp. TS-1

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag GBB76_RS08650 Protein ID WP_152302936.1
Coordinates 1801291..1801614 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag GBB76_RS08655 Protein ID WP_152302937.1
Coordinates 1801611..1801832 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBB76_RS08630 1796916..1798211 - 1296 WP_202911218.1 patatin-like phospholipase family protein -
GBB76_RS08635 1798360..1799139 - 780 WP_152302933.1 3-hydroxybutyrate dehydrogenase -
GBB76_RS08640 1799324..1799875 + 552 WP_152302934.1 transcriptional repressor -
GBB76_RS08645 1799976..1801283 + 1308 WP_152302935.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
GBB76_RS08650 1801291..1801614 - 324 WP_152302936.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GBB76_RS08655 1801611..1801832 - 222 WP_152302937.1 antitoxin MazE family protein Antitoxin
GBB76_RS08660 1802000..1803037 + 1038 WP_152302938.1 aspartate-semialdehyde dehydrogenase -
GBB76_RS08665 1803140..1803820 - 681 WP_162375532.1 methyltransferase domain-containing protein -
GBB76_RS08670 1804035..1804679 + 645 WP_152302940.1 DUF1007 family protein -
GBB76_RS08675 1804676..1805638 + 963 WP_152302941.1 nickel/cobalt transporter -
GBB76_RS08680 1805759..1806499 - 741 WP_152302942.1 acetoacetate decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-103)

Antitoxin

Antitoxin MazE-like

(6-67)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 11560.55 Da        Isoelectric Point: 8.8934

>T141283 WP_152302936.1 NZ_CP045144:c1801614-1801291 [Ancylobacter sp. TS-1]
MRRGDLVTVSLPGDFGKPRPGLIVQADEFGNIPSVTLLPLSSLLIDAPLVRLTVQPTALNGLREPSQVMIDKAMTVRRDK
VGAPFGRLEDDAMLAVNRSLAFFLGFA

Download         Length: 324 bp

>T141283 NZ_CP059917:c1679912-1679526 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8257.29 Da        Isoelectric Point: 6.2690

>AT141283 WP_152302937.1 NZ_CP045144:c1801832-1801611 [Ancylobacter sp. TS-1]
MATSVRQRVQRRRDALRAAGLRPVQIWVPDIRRPGFAEECRRQAGIVAAADASDSNLQSFMDAAWTDLFEPEE

Download         Length: 222 bp

>AT141283 NZ_CP059917:c1679536-1679207 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References