Detailed information of TA system TA141280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 452876..453426
• Replicon: chromosome
• Accession: NZ_CP045141
• Organism: Kingella kingae strain F41215CHC

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GB851_RS02330
• Protein ID: WP_003789642.1
• Coordinates: 453157..453426 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: F5S5C2
• Locus tag: GB851_RS02325
• Protein ID: WP_003785638.1
• Coordinates: 452876..453160 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GB851_RS02275	448065..448922	-	858	WP_164538069.1	tyrosine-type recombinase/integrase	-
GB851_RS02280	448985..449338	+	354	WP_003785632.1	phage holin family protein	-
GB851_RS02285	449464..449700	+	237	WP_003789355.1	transposase family protein	-
GB851_RS02290	449787..450248	+	462	WP_164538070.1	ISAs1 family transposase	-
GB851_RS02295	450255..450770	+	516	WP_164538071.1	glycoside hydrolase family 108 protein	-
GB851_RS02300	450767..451084	+	318	WP_003789633.1	hypothetical protein	-
GB851_RS02305	451081..451323	+	243	WP_003789635.1	Rz1-like lysis system protein LysC	-
GB851_RS02310	451307..451525	+	219	WP_032828138.1	TraR/DksA C4-type zinc finger protein	-
GB851_RS02315	451512..451943	+	432	WP_003789638.1	phage tail protein	-
GB851_RS02320	451947..452681	+	735	WP_003789640.1	phage virion morphogenesis protein	-
GB851_RS02325	452876..453160	+	285	WP_003785638.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GB851_RS02330	453157..453426	+	270	WP_003789642.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GB851_RS02335	453585..454193	+	609	WP_003789644.1	phage baseplate assembly protein V	-
GB851_RS02340	454190..454525	+	336	WP_003789646.1	GPW/gp25 family protein	-
GB851_RS02345	454522..455418	+	897	WP_003789648.1	baseplate J/gp47 family protein	-
GB851_RS02350	455415..455996	+	582	WP_003785645.1	phage tail protein I	-
GB851_RS02355	456014..457354	+	1341	WP_164538072.1	phage tail protein	-
GB851_RS02360	457367..457963	+	597	WP_164538073.1	phage tail protein	-
GB851_RS02365	457960..458421	+	462	WP_164538074.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	427530..459004	31474

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (7-77)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10260.87 Da
• Isoelectric Point: 6.7090

>T141280 WP_003789642.1 NZ_CP045141:453157-453426 [Kingella kingae]
MSREIIFQGQFKRDVKKQFLELATVEWAEVLTCLVNDLPLAEKYRDHALVNDKNGYRDCHIKPDLVLIYGSKENALILVR
LGSHSEIFG

Nucleotide

• Length: 270 bp

>T141280 NZ_CP045141:453157-453426 [Kingella kingae]
ATGAGCAGAGAAATTATTTTTCAAGGGCAGTTTAAGCGAGATGTGAAAAAGCAGTTTTTAGAGCTTGCGACAGTGGAATG
GGCAGAAGTTTTAACTTGTTTGGTAAATGATTTGCCGCTTGCTGAAAAATATCGCGACCATGCGCTTGTGAATGACAAAA
ACGGATACAGAGACTGCCATATCAAGCCTGATTTGGTTTTAATTTACGGCAGTAAAGAAAACGCCTTGATACTTGTTCGG
TTAGGTTCTCATTCCGAGATATTTGGCTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10648.21 Da
• Isoelectric Point: 7.0134

>AT141280 WP_003785638.1 NZ_CP045141:452876-453160 [Kingella kingae]
MSAINFNIRMDKSLKERAFPVIESYGLTPAQAVKLFFNQIATTQTIPISFEHNVNRIPNAITRKAIEDAESEFETAKRYK
TVEEAIAAMQELAK

Nucleotide

• Length: 285 bp

>AT141280 NZ_CP045141:452876-453160 [Kingella kingae]
ATGAGCGCAATAAATTTTAATATCCGTATGGATAAAAGTTTGAAAGAACGCGCATTTCCAGTCATTGAGAGCTACGGATT
AACGCCAGCACAAGCAGTCAAACTGTTTTTTAATCAGATTGCTACTACCCAAACCATTCCCATTTCATTTGAACACAACG
TAAACCGCATTCCTAATGCAATCACACGTAAAGCGATTGAAGATGCGGAATCCGAATTTGAGACAGCCAAACGCTATAAA
ACCGTTGAAGAAGCTATTGCAGCAATGCAGGAATTGGCGAAATGA

Structures

Antitoxin

• AlphaFold DB: F5S5C2