Detailed information of TA system TA141275

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1118861..1119632
• Replicon: chromosome
• Accession: NZ_CP045137
• Organism: Staphylococcus haemolyticus strain VB5326

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: GA597_RS05710
• Protein ID: WP_011275410.1
• Coordinates: 1119483..1119632 (+)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: Q4L7F8
• Locus tag: GA597_RS05705
• Protein ID: WP_011275409.1
• Coordinates: 1118861..1119460 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA597_RS05685 (GA597_11110)	1114744..1116198	+	1455	WP_011275405.1	ABC transporter substrate-binding protein/permease	-
GA597_RS05690 (GA597_11105)	1116191..1116913	+	723	WP_119890392.1	amino acid ABC transporter ATP-binding protein	-
GA597_RS05695 (GA597_11100)	1117091..1118218	+	1128	WP_011275407.1	tRNA epoxyqueuosine(34) reductase QueG	-
GA597_RS05700 (GA597_11095)	1118219..1118689	+	471	WP_011275408.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
GA597_RS05705 (GA597_11090)	1118861..1119460	+	600	WP_011275409.1	glucosamine-6-phosphate isomerase	Antitoxin
GA597_RS05710 (GA597_11085)	1119483..1119632	+	150	WP_011275410.1	SAS053 family protein	Toxin
GA597_RS05715 (GA597_11080)	1119843..1120238	+	396	WP_011275411.1	hypothetical protein	-
GA597_RS05720 (GA597_11075)	1120445..1121830	+	1386	WP_011275412.1	class II fumarate hydratase	-
GA597_RS05725 (GA597_11070)	1121896..1122720	-	825	WP_011275413.1	RluA family pseudouridine synthase	-
GA597_RS05730 (GA597_11065)	1122908..1124017	+	1110	WP_011275414.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5796.18 Da
• Isoelectric Point: 3.9484

>T141275 WP_011275410.1 NZ_CP045137:1119483-1119632 [Staphylococcus haemolyticus]
MTKNKDSELNYHEEENAMVQDLDDLKTLGKEMEQISEENDEDKLNQSHE

Nucleotide

• Length: 150 bp

>T141275 NZ_CP059910:c89802-89422 [Escherichia coli]
ATGAGACATATATCACCGGAAGAACTTGTTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCTGGCATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22272.12 Da
• Isoelectric Point: 4.7588

>AT141275 WP_011275409.1 NZ_CP045137:1118861-1119460 [Staphylococcus haemolyticus]
MAMNFKVFNDVEHVAEYTADIIRKQFNNNPTTIAGIHLTKDAAPVLDELKKDVDHNAVDFSQVNILDYDDNRSYYEALGV
PASQIYPINLDDDAESLIDDKIKTKENKGKLILQVTSIDESGSLNVNVRQGLLKAREVVLVVTGANKREVVKKLYEENGK
SSFEPSDLKAHRMVTVVLDRAAAEGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT141275 NZ_CP059910:c90023-89802 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Antitoxin

• AlphaFold DB: A0A2A1K9C2