Detailed information of TA system TA141273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 956283..956794
• Replicon: chromosome
• Accession: NZ_CP045137
• Organism: Staphylococcus haemolyticus strain VB5326

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: Q4L7W7
• Locus tag: GA597_RS04780
• Protein ID: WP_011275259.1
• Coordinates: 956588..956794 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: GA597_RS04775
• Protein ID: WP_011275258.1
• Coordinates: 956283..956576 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA597_RS04755 (GA597_12030)	951438..952313	+	876	WP_011275255.1	membrane protein insertase YidC	-
GA597_RS04760 (GA597_12025)	952508..953824	+	1317	WP_058646542.1	ISL3-like element ISSha1 family transposase	-
GA597_RS04765 (GA597_12020)	953871..954512	-	642	WP_016931420.1	HD domain-containing protein	-
GA597_RS04770 (GA597_12015)	954612..956096	-	1485	WP_066032128.1	cardiolipin synthase	-
GA597_RS04775 (GA597_12010)	956283..956576	+	294	WP_011275258.1	copper-sensing transcriptional repressor CsoR	Antitoxin
GA597_RS04780 (GA597_12005)	956588..956794	+	207	WP_011275259.1	heavy-metal-associated domain-containing protein	Toxin
GA597_RS04785 (GA597_12000)	956902..957039	+	138	WP_011275260.1	Lmo0850 family protein	-
GA597_RS04790 (GA597_11995)	957337..959013	+	1677	Protein_951	IS1182 family transposase	-
GA597_RS04795 (GA597_11990)	958988..960187	-	1200	WP_011275262.1	FtsW/RodA/SpoVE family cell cycle protein	-
GA597_RS04800 (GA597_11985)	960605..961675	+	1071	WP_011275263.1	D-alanine--D-alanine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	952508..959030	6522

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Metal-sensitive transcriptional repressor (3-95)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7857.79 Da
• Isoelectric Point: 4.0742

>T141273 WP_011275259.1 NZ_CP045137:956588-956794 [Staphylococcus haemolyticus]
MNFSEIRISELNTEEQANSLQHRLEKMIGVDEVIVELNDQLVKISYETPTNLNSIEKEIYDDGYKVLG

Nucleotide

• Length: 207 bp

>T141273 NZ_CP059908:c140276-140118 [Escherichia coli]
ATGAAACTACCACGCAGCTCTCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 11222.83 Da
• Isoelectric Point: 6.6361

>AT141273 WP_011275258.1 NZ_CP045137:956283-956576 [Staphylococcus haemolyticus]
MNNHENAHHSDQIKMNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLDHHMKSCIMDKVNNGAQ
EEAMEELLVTFQKLMKD

Nucleotide

• Length: 294 bp

>AT141273 NZ_CP059908:c140544-140320 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGATTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Toxin

• AlphaFold DB: A0A2A1K7I8