Detailed information of TA system TA141269

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 908638..909166
• Replicon: chromosome
• Accession: NZ_CP045135
• Organism: Acinetobacter indicus strain XG01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: GA636_RS04400
• Protein ID: WP_000221358.1
• Coordinates: 908873..909166 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA636_RS04395
• Protein ID: WP_160232258.1
• Coordinates: 908638..908883 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA636_RS04375	903807..905711	+	1905	WP_160232257.1	copper resistance system multicopper oxidase	-
GA636_RS04380	905698..906036	+	339	WP_004897649.1	hypothetical protein	-
GA636_RS04385	906023..906967	+	945	WP_004668309.1	copper resistance protein B	-
GA636_RS04390	907199..908528	+	1330	Protein_836	ISNCY family transposase	-
GA636_RS04395	908638..908883	+	246	WP_160232258.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GA636_RS04400	908873..909166	+	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA636_RS04405	909295..909624	-	330	WP_004641881.1	four-helix bundle copper-binding protein	-
GA636_RS04410	909871..910961	+	1091	Protein_840	IS3 family transposase	-
GA636_RS04415	911676..912239	+	564	WP_005180661.1	alkyl hydroperoxide reductase subunit C	-
GA636_RS04420	912441..913316	+	876	WP_160232259.1	pirin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	aph(3'')-Ib / aph(6)-Id / sul2	-	878272..923273	45001
	-	inside	IScluster/Tn	-	-	898070..910961	12891

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T141269 WP_000221358.1 NZ_CP045135:908873-909166 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T141269 NZ_CP059907:c5103024-5102647 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCAGGAACTTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT141269 WP_160232258.1 NZ_CP045135:908638-908883 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALISEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT141269 NZ_CP059907:c5103445-5103071 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGACATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCACCCGCAATCACCTCATAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4