Detailed information of TA system TA141268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 852331..852859
• Replicon: chromosome
• Accession: NZ_CP045135
• Organism: Acinetobacter indicus strain XG01

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: GA636_RS04075
• Protein ID: WP_000221358.1
• Coordinates: 852331..852624 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GA636_RS04080
• Protein ID: WP_160232242.1
• Coordinates: 852614..852859 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA636_RS04045	847538..848509	-	972	WP_005176780.1	helix-turn-helix domain-containing protein	-
GA636_RS04050	848642..849526	+	885	WP_160232241.1	MBL fold metallo-hydrolase	-
GA636_RS04055	849611..850153	+	543	WP_004637127.1	cysteine hydrolase	-
GA636_RS04060	850228..850521	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GA636_RS04065	850511..850756	-	246	WP_160232242.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
GA636_RS04070	850924..852252	+	1329	Protein_773	ISNCY family transposase	-
GA636_RS04075	852331..852624	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GA636_RS04080	852614..852859	-	246	WP_160232242.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GA636_RS04085	853242..854389	+	1148	Protein_776	IS3 family transposase	-
GA636_RS04090	854451..854948	+	498	Protein_777	IS982 family transposase	-
GA636_RS04095	854993..855702	+	710	Protein_778	IS6-like element IS1006 family transposase	-
GA636_RS04100	855874..856068	-	195	WP_004281879.1	heavy-metal-associated domain-containing protein	-
GA636_RS04105	856538..857419	-	882	WP_004668321.1	CopD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	842135..855702	13567

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T141268 WP_000221358.1 NZ_CP045135:c852624-852331 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T141268 NZ_CP059907:c4946342-4946154 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTATCCGTATTCGCCCTCCAGAACGGCTTAACA
CAATCCTTTTACTGGTAGACGGCTCATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9265.64 Da
• Isoelectric Point: 4.3142

>AT141268 WP_160232242.1 NZ_CP045135:c852859-852614 [Acinetobacter indicus]
MATVNFRVDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT141268 NZ_CP059907:c4946578-4946345 [Escherichia coli]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAATACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4