Detailed information of TA system TA141264

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1464024..1465139
• Replicon: chromosome
• Accession: NZ_CP045131
• Organism: Acinetobacter indicus strain TQ18

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: GA721_RS06885
• Protein ID: WP_016658124.1
• Coordinates: 1464024..1464188 (-)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: GA721_RS06890
• Protein ID: WP_160243170.1
• Coordinates: 1464270..1465139 (-)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA721_RS06870	1460001..1461023	+	1023	WP_160243166.1	ferredoxin reductase	-
GA721_RS06875	1461047..1462204	+	1158	WP_171065080.1	acyl-CoA desaturase	-
GA721_RS06880	1462506..1463924	+	1419	WP_160243168.1	iron-containing redox enzyme family protein	-
GA721_RS06885	1464024..1464188	-	165	WP_016658124.1	hypothetical protein	Toxin
GA721_RS06890	1464270..1465139	-	870	WP_160243170.1	SDR family oxidoreductase	Antitoxin
GA721_RS06895	1465235..1465483	-	249	WP_160243172.1	DUF2171 domain-containing protein	-
GA721_RS06900	1466142..1467383	+	1242	WP_016658127.1	MFS transporter	-
GA721_RS06905	1467823..1468107	+	285	WP_160243174.1	KGG domain-containing protein	-
GA721_RS06910	1468296..1468745	-	450	WP_005178047.1	cyanase	-
GA721_RS06915	1469039..1469848	+	810	WP_005178046.1	formate/nitrite transporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T141264 WP_016658124.1 NZ_CP045131:c1464188-1464024 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T141264 NZ_CP059907:4070676-4071062 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31875.98 Da
• Isoelectric Point: 4.8531

>AT141264 WP_160243170.1 NZ_CP045131:c1465139-1464270 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNELIDYAGTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT141264 NZ_CP059907:4071052-4071381 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Toxin

• AlphaFold DB: V2U6R6