Detailed information of TA system TA141260

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1555117..1556232
• Replicon: chromosome
• Accession: NZ_CP045129
• Organism: Acinetobacter indicus strain TQ04

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: GA660_RS07315
• Protein ID: WP_016658124.1
• Coordinates: 1555117..1555281 (-)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: GA660_RS07320
• Protein ID: WP_160241308.1
• Coordinates: 1555363..1556232 (-)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GA660_RS07300	1551094..1552116	+	1023	WP_160241305.1	ferredoxin reductase	-
GA660_RS07305	1552140..1553297	+	1158	WP_171502424.1	fatty acid desaturase	-
GA660_RS07310	1553599..1555017	+	1419	WP_160241307.1	iron-containing redox enzyme family protein	-
GA660_RS07315	1555117..1555281	-	165	WP_016658124.1	hypothetical protein	Toxin
GA660_RS07320	1555363..1556232	-	870	WP_160241308.1	SDR family oxidoreductase	Antitoxin
GA660_RS07325	1556335..1556574	-	240	WP_104471337.1	DUF2171 domain-containing protein	-
GA660_RS07330	1557233..1558474	+	1242	WP_016658127.1	MFS transporter	-
GA660_RS07335	1558912..1559196	+	285	WP_160241309.1	KGG domain-containing protein	-
GA660_RS07340	1559385..1559834	-	450	WP_005178047.1	cyanase	-
GA660_RS07345	1560127..1560936	+	810	WP_005178046.1	formate/nitrite transporter family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T141260 WP_016658124.1 NZ_CP045129:c1555281-1555117 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T141260 NZ_CP059907:c3143230-3143036 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31955.08 Da
• Isoelectric Point: 5.1167

>AT141260 WP_160241308.1 NZ_CP045129:c1556232-1555363 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKNHYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGRQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNQLIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT141260 NZ_CP059907:3142859-3143037 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: V2U6R6