Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 979936..980576 Replicon chromosome
Accession NZ_CP045121
Organism Rubrobacter sp. SCSIO 52915

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GBA65_RS04905 Protein ID WP_166395628.1
Coordinates 980172..980576 (+) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GBA65_RS04900 Protein ID WP_207956155.1
Coordinates 979936..980175 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBA65_RS04885 975030..975821 + 792 WP_166395625.1 hypothetical protein -
GBA65_RS04890 976114..976626 + 513 WP_166395626.1 hypothetical protein -
GBA65_RS04895 976691..979834 + 3144 WP_166395627.1 EAL domain-containing protein -
GBA65_RS04900 979936..980175 + 240 WP_207956155.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
GBA65_RS04905 980172..980576 + 405 WP_166395628.1 type II toxin-antitoxin system VapC family toxin Toxin
GBA65_RS04910 980679..981305 - 627 WP_166395629.1 nitrile hydratase subunit alpha -
GBA65_RS04915 981316..981618 - 303 WP_207956156.1 nitrile hydratase subunit beta -
GBA65_RS04920 981615..981920 - 306 WP_166395630.1 nitrile hydratase subunit beta -
GBA65_RS04925 981865..982947 - 1083 WP_166398348.1 glycosyltransferase -
GBA65_RS04930 983024..984592 - 1569 WP_166395631.1 GspE/PulE family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(8-43)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 14492.60 Da        Isoelectric Point: 4.5702

>T141254 WP_166395628.1 NZ_CP045121:980172-980576 [Rubrobacter sp. SCSIO 52915]
VILLLDTNICIYLIRGRPPEALRRFEGYAVGEIGVSSITVAELHFGVSKSRQPEKNRQALEQFLLALEIVGFDGNAAVAY
GRIRAELEAKGTPIGPLDTLIAAQAIALDSTLVTNNIGEFSRVPGLEVEDWSSV

Download         Length: 405 bp

>T141254 NZ_CP059907:1793796-1794203 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9355.53 Da        Isoelectric Point: 4.8898

>AT141254 WP_207956155.1 NZ_CP045121:979936-980175 [Rubrobacter sp. SCSIO 52915]
MVKTAKLFSNGRSQAVRLPKEFRFEGDEVYIKRVGNAVVLLPRRGSWQGLYESLERFSDDFMEEREQPVWEEERESPFA

Download         Length: 240 bp

>AT141254 NZ_CP059907:1793549-1793815 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References