Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/DUF433(antitoxin)
Location 894917..895491 Replicon chromosome
Accession NZ_CP045121
Organism Rubrobacter sp. SCSIO 52915

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GBA65_RS04475 Protein ID WP_166395560.1
Coordinates 895138..895491 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GBA65_RS04470 Protein ID WP_166395559.1
Coordinates 894917..895141 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBA65_RS04450 890615..891229 - 615 WP_166395555.1 tetratricopeptide repeat protein -
GBA65_RS04455 891226..891831 - 606 WP_166395556.1 tetratricopeptide repeat protein -
GBA65_RS04460 891844..892437 - 594 WP_166395557.1 DUF1802 family protein -
GBA65_RS04465 892521..893918 + 1398 WP_166395558.1 class II fumarate hydratase -
GBA65_RS04470 894917..895141 + 225 WP_166395559.1 DUF433 domain-containing protein Antitoxin
GBA65_RS04475 895138..895491 + 354 WP_166395560.1 DUF5615 family PIN-like protein Toxin
GBA65_RS04480 895703..896104 + 402 WP_166395561.1 hypothetical protein -
GBA65_RS04485 896109..898664 + 2556 WP_207956137.1 DUF4132 domain-containing protein -
GBA65_RS04490 898733..899125 + 393 WP_166395562.1 hypothetical protein -
GBA65_RS04495 899271..899822 + 552 WP_166395563.1 peptide-methionine (S)-S-oxide reductase MsrA -
GBA65_RS04500 899940..900317 + 378 WP_166395564.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Domain of unknown function DUF5615

(1-77)

Antitoxin

Protein of unknown function DUF433

(8-63)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13059.96 Da        Isoelectric Point: 4.2805

>T141253 WP_166395560.1 NZ_CP045121:895138-895491 [Rubrobacter sp. SCSIO 52915]
MIVWIDAQLSPYLARWLSSEFGVEAKPVRELGLRDAKDREIFLEAREAGTVVLTKDSDFVLLLEQLGSPPQVLWLDAGNT
LNARLREVLAQTFPAVRDLLLRGEPLVEISEAESTNA

Download         Length: 354 bp

>T141253 NZ_CP059907:c1591104-1590727 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8126.40 Da        Isoelectric Point: 4.7360

>AT141253 WP_166395559.1 NZ_CP045121:894917-895141 [Rubrobacter sp. SCSIO 52915]
MAELMNRITADPEQCGGRPCIRGKRIRVSDVLDLLANGLSPMEIVEEVPDLELEDVGASLRFASRRLNHPLVAA

Download         Length: 225 bp

>AT141253 NZ_CP059907:c1591525-1591151 [Escherichia coli]
GTGTCAGACACACACCCCGGGACAACGCATCCCGACAACAACAACGACCGCCCCTGGTGGGGGCTCCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGCAATCAGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGGCAGT
TTAGCGACGCGGATGCGTATCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References