Detailed information of TA system TA141251

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 3212668..3213259
• Replicon: chromosome
• Accession: NZ_CP045119
• Organism: Rubrobacter sp. SCSIO 52909

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: GBA63_RS16245
• Protein ID: WP_166177758.1
• Coordinates: 3212993..3213259 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GBA63_RS16240
• Protein ID: WP_207956843.1
• Coordinates: 3212668..3212988 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GBA63_RS16215	3208204..3208575	-	372	WP_166177748.1	DoxX family protein	-
GBA63_RS16220	3208740..3209321	+	582	WP_166177750.1	YdeI/OmpD-associated family protein	-
GBA63_RS16225	3209461..3211257	+	1797	WP_207956842.1	translational GTPase TypA	-
GBA63_RS16230	3211429..3212166	+	738	WP_166177754.1	SDR family oxidoreductase	-
GBA63_RS16235	3212403..3212621	-	219	WP_166177756.1	DUF4926 domain-containing protein	-
GBA63_RS16240	3212668..3212988	-	321	WP_207956843.1	toxin-antitoxin system HicB family antitoxin	Antitoxin
GBA63_RS16245	3212993..3213259	-	267	WP_166177758.1	type II toxin-antitoxin system HicA family toxin	Toxin
GBA63_RS16250	3213322..3216885	-	3564	WP_166177760.1	PAS domain S-box protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (25-75)

Antitoxin

• Uncharacterised protein family HicB (52-102)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9896.34 Da
• Isoelectric Point: 10.5421

>T141251 WP_166177758.1 NZ_CP045119:c3213259-3212993 [Rubrobacter sp. SCSIO 52909]
MNLSSKHHKTLQAVFEVPVRPNVAWADVERLFRALGAEVSEGRGSRVRVYLGGIRAVFHRPHPQKETDKGALMSVRRFLV
EAGYEPGE

Nucleotide

• Length: 267 bp

>T141251 NZ_CP059907:c1356993-1356529 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12319.53 Da
• Isoelectric Point: 4.2389

>AT141251 WP_207956843.1 NZ_CP045119:c3212988-3212668 [Rubrobacter sp. SCSIO 52909]
MLQYKGYTGQVEFDDEAGLFHGEVVDLRDVVTFQGTSVEELEEAFRDSVDDYLEFCEERGEEPDRPFSGRLMLRVSPQLH
RQAYTRARQEGKSLNQWISERLEQAG

Nucleotide

• Length: 321 bp

>AT141251 NZ_CP059907:c1357328-1356993 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA