Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3858184..3859431 Replicon chromosome
Accession NZ_CP045118
Organism Pseudomonas sp. SCB32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GA645_RS17570 Protein ID WP_152224275.1
Coordinates 3858865..3859431 (+) Length 189 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GA645_RS17565 Protein ID WP_152224274.1
Coordinates 3858184..3858741 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GA645_RS17545 3853443..3854933 - 1491 WP_152224270.1 aldehyde dehydrogenase -
GA645_RS17550 3855447..3856109 + 663 WP_152224271.1 dihydrofolate reductase family protein -
GA645_RS17555 3856126..3857025 - 900 WP_152224272.1 LysR family transcriptional regulator -
GA645_RS17560 3857131..3858105 + 975 WP_152224273.1 DMT family transporter -
GA645_RS17565 3858184..3858741 + 558 WP_152224274.1 helix-turn-helix domain-containing protein Antitoxin
GA645_RS17570 3858865..3859431 + 567 WP_152224275.1 HD domain-containing protein Toxin
GA645_RS17575 3859878..3860234 + 357 WP_152224276.1 metalloregulator ArsR/SmtB family transcription factor -
GA645_RS17580 3860287..3861291 + 1005 WP_152224277.1 ArsJ-associated glyceraldehyde-3-phosphate dehydrogenase -
GA645_RS17585 3861309..3862544 + 1236 WP_152228175.1 organoarsenical effux MFS transporter ArsJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-167)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-44)


Sequences

Toxin        


Download         Length: 189 a.a.        Molecular weight: 20893.55 Da        Isoelectric Point: 5.1034

>T141246 WP_152224275.1 NZ_CP045118:3858865-3859431 [Pseudomonas sp. SCB32]
MRDQGIHDKLAFLRQAEKLKSVLRSAHTSTGRRESTAEHSWRLALLAMVFAEDLGDLDLCKVLQLCLIHDLGEALSGDVP
AVDVQAHGNKGDSERQDLLCMTSPLAAPLRERILSLYDEYEAAATAEAQAVKALDKLETILQHTQGQNPPDFNYEFNLGY
GRRYTDATPFLASLREVLDDETRKRAAG

Download         Length: 567 bp

>T141246 NZ_CP059907:942010-942117 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20300.28 Da        Isoelectric Point: 8.1928

>AT141246 WP_152224274.1 NZ_CP045118:3858184-3858741 [Pseudomonas sp. SCB32]
MTSPPLHHTPLGPMLKRWRLLHRVKQSHAADMFRVSQSTISRWEARAQEAEPEQRARIEALLKARLDSAADHALARLVAC
SSQPVHLVCDLTHRLLACSASRAAEFSVPVAGLMGRSLWPLATEEIAAQESTLDSLGWREGIAAPALEFATGTNGSLLVP
IHQSQCRWTRLTLSDGSTARLVETL

Download         Length: 558 bp

>AT141246 NZ_CP059907:c941953-941895 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References